The present study investigates the performance of a hybrid solar thermal membrane-based multigeneration system for generating power, cooling, heating, and water. The integrated arrangement consists of organic Rankine cycle (ORC), Kalina cycle (KC), ammonia-water refrigeration, Pressure retarded osmosis (PRO) and forward osmosis (FO). A comprehensive multicriteria assessment of energy, exergy, economic, environmental, and emergy (5 E) is conducted to ensure a systematic examination. The results indicate that the allocation of R113 in the ORC yielded the highest exergetic efficiency and energy cost of 46.61% and 0.08109 $/kWh, respectively. Additionally, the system achieved the lowest environmental impact of 1694 mPts.h-1 when employing R718. The utilization of rejected water-ammonia in the PRO and FO modules achieves a reasonable power density and water flux of 17.5 W m- 2 and 67.94 l m- 2h-1, respectively. Finally, emergy-based sustain-ability analysis revealed that the proposed system obtains a sustainability index of 0.73, which is greater than that of the fossil fuel-based power generation systems. Comparison of three considered scenarios based on emergy and economic analysis demonstrated that fossil fuel driven system is not providing sustainable products even with a 72.3% decrease in initial capital cost. For further improvements, we highlight several areas for additional research and provide recommendations for existing solar-and membrane-driven systems.