Calcium Homeostasis in the Development of Resistant Breast Tumors

被引：2

作者：

Martin-Garcia, Desiree ^{[1
,2
]}

Tellez, Teresa ^{[1
,2
,3
,4
]}

Redondo, Maximino ^{[1
,2
,3
,4
,5
]}

Garcia-Aranda, Marilina ^{[2
,3
,4
,5
]}

机构：

[1] Univ Malaga, Fac Med, Surg Specialties Biochem & Immunol Dept, Malaga 29010, Spain

[2] Inst Invest Biomed Malaga, BIONAND, Plataforma BIONAND, Severo Ochoa 35, Malaga 29590, Spain

[3] Inst Invest Biomed Malaga IBIMA, Red Invest Serv Salud Enfermedades Cron REDISSEC, Malaga 29590, Spain

[4] Inst Invest Biomed Malaga IBIMA, Red Invest Cronicidad Atenc Primaria & Promoc Sal, Malaga 29590, Spain

[5] Hosp Costa del Sol, Res & Innovat Unit, Autovia A 7 Km 187, Marbella 29602, Spain

来源：

CANCERS | 2023年 / 15卷 / 11期

关键词：

breast cancer; calcium; resistant tumors; targeted therapy; homeostasis; Ca2+ channels; PATIENT-LEVEL METAANALYSIS; INTRACELLULAR CALCIUM; INDUCED APOPTOSIS; PLASMA-MEMBRANE; CA2+ CHANNEL; CANCER RISK; PHASE-II; 12-LIPOXYGENASE INHIBITION; CUTANEOUS METASTASES; AROMATASE INHIBITORS;

D O I：

10.3390/cancers15112872

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is one of the main health problems worldwide. Only in 2020, this disease caused more than 19 million new cases and almost 10 million deaths, with breast cancer being the most diagnosed worldwide. Today, despite recent advances in breast cancer treatment, a significant percentage of patients will either not respond to therapy or will eventually experience lethal progressive disease. Recent studies highlighted the involvement of calcium in the proliferation or evasion of apoptosis in breast carcinoma cells. In this review, we provide an overview of intracellular calcium signaling and breast cancer biology. We also discuss the existing knowledge on how altered calcium homeostasis is implicated in breast cancer development, highlighting the potential utility of Ca2+ as a predictive and prognostic biomarker, as well as its potential for the development of new pharmacological treatments to treat the disease.

引用

页数：22

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