Selective [3+2] cycloaddition reaction of isothiazol-3(2h)-ones with in situ formed azomethine ylide to thiazolidines and oxazolidines

被引：4

作者：

Jin, Wen Bin ^{[1
,2
,3
]}

Wang, Zhen ^{[2
,3
,4
]}

Yang, Wei ^{[1
]}

Zhang, Die ^{[1
]}

Ning, Jin Hua ^{[1
]}

Ke, Jing ^{[1
]}

Hou, An Guo ^{[1
]}

Chen, Lin Yun ^{[1
]}

Ma, Yun Shu ^{[1
]}

机构：

[1] Yunnan Univ Chinese Med, Key Lab External Drug Delivery Syst & Preparat Tec, Kunming, Peoples R China

[2] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

[4] Patent Examinat Cooperat Hubei Ctr Patent Off, Wuhan, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 08期

基金：

中国国家自然科学基金;

关键词：

1,3-DIPOLAR CYCLOADDITION; ENANTIOSPECIFIC SYNTHESIS; BIOLOGICAL EVALUATION; DERIVATIVES; YM461; TENELIGLIPTIN; PYRROLIDINE; BEARING; DESIGN;

D O I：

10.1002/jhet.4668

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel selective [3 + 2] cycloaddition reactions between in situ formed nonstabilized azomethine ylide generated from N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine enabled by Lewis acids and bioactive molecules isothiazol-3(2H)-ones have been developed. The reaction selectively afforded novel thiazolidines or cyclo-fused oxazolidinones depending on Lewis acid catalyst system of reaction used.

引用

页码：1383 / 1393

页数：11

共 62 条

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