Selective [3+2] cycloaddition reaction of isothiazol-3(2h)-ones with in situ formed azomethine ylide to thiazolidines and oxazolidines

被引:4
作者
Jin, Wen Bin [1 ,2 ,3 ]
Wang, Zhen [2 ,3 ,4 ]
Yang, Wei [1 ]
Zhang, Die [1 ]
Ning, Jin Hua [1 ]
Ke, Jing [1 ]
Hou, An Guo [1 ]
Chen, Lin Yun [1 ]
Ma, Yun Shu [1 ]
机构
[1] Yunnan Univ Chinese Med, Key Lab External Drug Delivery Syst & Preparat Tec, Kunming, Peoples R China
[2] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Hong Kong, Peoples R China
[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China
[4] Patent Examinat Cooperat Hubei Ctr Patent Off, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
1,3-DIPOLAR CYCLOADDITION; ENANTIOSPECIFIC SYNTHESIS; BIOLOGICAL EVALUATION; DERIVATIVES; YM461; TENELIGLIPTIN; PYRROLIDINE; BEARING; DESIGN;
D O I
10.1002/jhet.4668
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Novel selective [3 + 2] cycloaddition reactions between in situ formed nonstabilized azomethine ylide generated from N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine enabled by Lewis acids and bioactive molecules isothiazol-3(2H)-ones have been developed. The reaction selectively afforded novel thiazolidines or cyclo-fused oxazolidinones depending on Lewis acid catalyst system of reaction used.
引用
收藏
页码:1383 / 1393
页数:11
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