Single-Atom Gadolinium Nano-Contrast Agents with High Stability for Tumor T1 Magnetic Resonance Imaging

被引：32

作者：

Liu, Shange ^{[3
]}

Jiang, Yuxing ^{[1
]}

Liu, Pengcheng ^{[4
]}

Yi, Yu ^{[1
]}

Hou, Dayong ^{[1
]}

Li, You ^{[3
]}

Liang, Xiao ^{[5
]}

Wang, Yifan ^{[3
]}

Li, Zhi ^{[6
]}

He, Jia ^{[4
]}

Rong, Hongpan ^{[3
]}

Wang, Dingsheng ^{[5
]}

Zhang, Jiatao ^{[2
]}

机构：

[1] Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Beijing Inst Technol, Sch Mat Sci & Engn, Beijing Key Lab Construct Tailorable Adv Funct Mat, Beijing 100081, Peoples R China

[3] Beijing Inst Technol, Inst Engn Med, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharmac, Beijing Key Lab Construct Tailorable Adv Funct Mat, Beijing 100081, Peoples R China

[4] Tianjin Univ Technol, Tianjin 300384, Peoples R China

[5] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[6] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China

来源：

ACS NANO | 2023年 / 17卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Single-atom nanomaterial; gadolinium; contrast agents; MRI; tumor imaging; MRI; NANOPARTICLES; CLEARANCE; DOTS;

D O I：

10.1021/acsnano.2c09664

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gadolinium chelates for tumor magnetic reso-nance imaging (MRI) face challenges such as inadequate sensitivity, lack of selectivity, and risk of Gd leakage. This study presents a single-atom Gd nano-contrast agent (Gd-SA) that enhances tumor MRI. Isolated Gd atoms coordinated by six N atoms and two O atoms are atomically dispersed on a hollow carbon nanosphere, allowing the maximum utilization of Gd atoms with reduced risk of toxic Gd ion leakage. Owning to the large surface area and fast exchange of relaxed water molecules, Gd-SA shows excellent T1-weighted magnetic resonance enhancement with a r1 value of 11.05 mM-1 s-1 at 7 T, which is 3.6 times that of the commercial gadolinium-diethylenetri-amine pentaacetic acid (Gd-DTPA). In vivo MRI results show that the Gd-SA has a higher spatial resolution and a wider imaging time window for tumors than Gd-DTPA, with low hematological, hepatic, and nephric toxicities. These advantages demonstrate the great potential of single-atom Gd-based nanomaterials as safe, efficient, and long-term MRI contrast agents for cancer diagnosis.

引用

页码：8053 / 8063

页数：11

共 62 条

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