Response to selpercatinib in a patient with RET fusion-positive pulmonary large-cell neuroendocrine carcinoma: A case report

被引:6
作者
Arora, Aakriti [1 ]
Zaemes, Jacob [2 ]
Ozdemirli, Metin [3 ]
Kim, Chul [2 ]
机构
[1] MedStar Washington Hosp Ctr, Dept Med, Washington, DC USA
[2] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA
[3] MedStar Georgetown Univ Hosp, Dept Pathol, Washington, DC USA
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
RET fusion; large cell neuroendocrine carcinoma; selpercatinib; lung cancer (LC); targeted; LUNG-CARCINOMA; FEATURES;
D O I
10.3389/fonc.2023.1134151
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Large-cell neuroendocrine carcinoma (LCNEC) is a rare subtype of non-small-cell lung cancer associated with a poor prognosis. LCNEC is genetically heterogeneous, and studies have revealed distinct molecular subtypes of LCNEC, which may have therapeutic implications. Herein, we present a case of a patient with stage IV LCNEC harboring a KIF5B-RET fusion whose disease responded to the selective RET inhibitor selpercatinib both extra- and intra-cranially, highlighting the importance of comprehensive molecular testing in LCNEC for selection of optimal treatment.
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页数:5
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