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Clinical and economic impact of clinical oncology pharmacy in cancer patients receiving injectable anticancer treatments: a systematic review
被引:7
作者:
Lattard, Claire
[1
]
Baudouin, Amandine
[1
]
Larbre, Virginie
[1
,2
]
Herledan, Chloe
[1
,2
]
Cerutti, Ariane
[1
]
Cerfon, Marie-Anne
[1
]
Kimbidima, Reine
[1
]
Caffin, Anne-Gaelle
[1
]
Vantard, Nicolas
[1
]
Schwiertz, Verane
[1
]
Ranchon, Florence
[1
,2
]
Rioufol, Catherine
[1
,2
]
机构:
[1] Hosp Civils Lyon, Unite Pharm Clin Oncol, Groupement Hospitalier Sud, Pierre Benite, France
[2] Univ Lyon 1, EA 3738, CICLY Ctr Innovat Cancerol Lyon, F-69921 Lyon, Oullins, France
关键词:
Cancer;
Clinical pharmacy;
Injectable anticancer drugs;
Clinical pharmacist;
POTENTIAL-DRUG INTERACTIONS;
HERBAL MEDICINE USE;
PHARMACEUTICAL CARE;
ADVERSE EVENTS;
CHEMOTHERAPY;
SERVICES;
INTERVENTIONS;
MANAGEMENT;
OUTCOMES;
PROGRAM;
D O I:
10.1007/s00432-023-04630-4
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
PurposeClinical pharmacy can reduce drug-related iatrogenesis by improving the management of adverse effects of drugs, limiting drug-drug interactions, and improving patient adherence. Given the vulnerability of cancer patients and the toxicity of injectable anticancer drugs, clinical pharmacy service (CPS) could provide a significant clinical benefit in cancer care. This review aims to synthesize existing evidence on clinical pharmacy's impact on patients treated with intravenous anticancer drugs.MethodsA comprehensive search was performed in the PubMed/Medline database from January 2000 to December 2021, associating the keywords: clinical pharmacy, pharmaceutical care, pharmacist, oncology, and chemotherapy. To be eligible for inclusion, studies have to report clinical pharmaceutical services for patients treated with intravenous chemotherapy with a clinical and/or economic impact.ResultsForty-one studies met the selection criteria. Various CPS were reported: medication reconciliation, medication review, and pharmaceutical interview with patient. There was a lack of randomized study (n = 3; 7.3%). In one randomized controlled trial, pharmaceutical intervention significantly improved quality of life of patients receiving pharmaceutical care during injectable anticancer drugs courses. Economical results appear to show positive impact of clinical pharmacy with cost savings reported from 3112.87$ to 249 844euro. Although most studies were non-comparative, they highlighted that clinical pharmacy tend to limit chemotherapy side effects and drug-related problems, improve quality of life and satisfaction of patients and healthcare professional, and a positive economic impact.ConclusionClinical pharmacy can reduce adverse drug events in cancer patients. More robust and economic evaluations are still required to support its development in everyday practice.
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页码:7905 / 7924
页数:20
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