Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities

被引：5

作者：

Liu, Dahai ^{[1
]}

Li, Jie ^{[1
]}

Qi, Fei ^{[2
]}

You, Hua ^{[3
,4
]}

机构：

[1] Foshan Univ, Sch Med, Foshan, Guangdong, Peoples R China

[2] Peking Univ Shenzhen Hosp, Dept Pulm & Crit Care Med, Shenzhen, Peoples R China

[3] Chongqing Med Univ, Childrens Hosp, Dept Pediat Hematol & Oncol, Chongqing, Peoples R China

[4] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Lab Excellence Syst Biomed Pediat Oncol, Chongqing Key Lab Pediat,Minist Educ Key Lab Chi, Chongqing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 12卷

基金：

中国国家自然科学基金;

关键词：

pancreatic cancer; semaphorins; mechanisms; Sema3; Sema4D; ANTIBODY BLOCKADE; TUMOR-GROWTH; 4D; METASTASIS; NEUROPILIN-1; PROGRESSION; EXPRESSION; INVASION; BINDING; 3C;

D O I：

10.3389/fonc.2022.1106762

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new markers for PC is self-evident. Semaphorins (Semas) have been shown to affect angiogenesis and lymphangiogenesis and can also directly affect the behavior of tumor cells. The expression and related action targets of its family members on PC are summarized in this review.

引用

页数：7

共 52 条

[1]

Alto LT, 2017, METHODS MOL BIOL, V1493, P1, DOI 10.1007/978-1-4939-6448-2_1

[2] Importance of semaphorins in cancer immunity [J].

Chen, Li-Han ;

Cuang, Eric Y. .

TRANSLATIONAL LUNG CANCER RESEARCH, 2019, 8 :S468-S470

[3] Long noncoding RNA DIO3OS interacts with miR-122 to promote proliferation and invasion of pancreatic cancer cells through upregulating ALDOA [J].

Cui, Kang ;

Jin, Shuiling ;

Du, Yabing ;

Yu, Junlin ;

Feng, Han ;

Fan, Qingxia ;

Ma, Wang .

CANCER CELL INTERNATIONAL, 2019, 19 (1)

[4]

Evans EE., 2015, J IMMUNOTHER CANCER, V3, P1, DOI [10.1186/2051-1426-3-S2-P220, DOI 10.1186/2051-1426-3-S2-P220]

[5] Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies [J].

Evans, Elizabeth E. ;

Jonason, Alan S., Jr. ;

Bussler, Holm ;

Torno, Sebold ;

Veeraraghavan, Janaki ;

Reilly, Christine ;

Doherty, Michael A. ;

Seils, Jennifer ;

Winter, Laurie A. ;

Mallow, Crystal ;

Kirk, Renee ;

Howell, Alan ;

Giralico, Susan ;

Scrivens, Maria ;

Klimatcheva, Katya ;

Fisher, Terrence L. ;

Bowers, William J. ;

Paris, Mark ;

Smith, Ernest S. ;

Zauderer, Maurice .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (06) :689-701

[6] Semaphorins in health and disease [J].

Fard, Damon ;

Tamagnone, Luca .

CYTOKINE & GROWTH FACTOR REVIEWS, 2021, 57 :55-63

[7] Netrins & Semaphorins: Novel regulators of the immune response [J].

Feinstein, Jordyn ;

Ramkhelawon, Bhama .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (12) :3183-3189

[8] Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer [J].

Foley, Kelly ;

Rucki, Agnieszka A. ;

Xiao, Qian ;

Zhou, Donger ;

Leubner, Ashley ;

Mo, Guanglan ;

Kleponis, Jennifer ;

Wu, Annie A. ;

Sharma, Rajni ;

Jiang, Qingguang ;

Anders, Robert A. ;

Iacobuzio-Donahue, Christine A. ;

Hajjar, Katherine A. ;

Maitra, Anirban ;

Jaffee, Elizabeth M. ;

Zheng, Lei .

SCIENCE SIGNALING, 2015, 8 (388)

[9]

Gao X., 2017, THESIS LANZHOU U GAN

[10]

[高增法 Gao Zengfa], 2016, [基础医学与临床, Basic & Clinical Medicine], V36, P891

← 1 2 3 4 5 6 →