Hydroxychloroquine dose: balancing toxicity and SLE flare risk

被引：12
作者：
Lenfant, Tiphaine [1 ,2 ]
Costedoat-Chalumeau, Nathalie [1 ,2 ]
机构：
[1] Cochin Hosp, AP HP, Dept Internal Med, Ctr Reference Malad Autoimmunes & Syst Rares Fran, Paris, France
[2] Univ Paris Cite CRESS, Ctr Epidemiol & Stat, INSERM, U1153, Paris, France
来源：
NATURE REVIEWS RHEUMATOLOGY | 2023年 / 19卷 / 01期
关键词：
RETINOPATHY;
D O I：
10.1038/s41584-022-00868-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out?
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页码：6 / 7
页数：2
相关论文
共 10 条
  • [1] Flares after hydroxychloroquine reduction or discontinuation: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
    Almeida-Brasil, Celline C.
    Hanly, John G.
    Urowitz, Murray
    Clarke, Ann Elaine
    Ruiz-Irastorza, Guillermo
    Gordon, Caroline
    Ramsey-Goldman, Rosalind
    Petri, Michelle
    Ginzler, Ellen M.
    Wallace, D. J.
    Bae, Sang-Cheol
    Romero-Diaz, Juanita
    Dooley, Mary Anne
    Peschken, Christine
    Isenberg, David
    Rahman, Anisur
    Manzi, Susan
    Jacobsen, Soren
    Lim, Sam
    van Vollenhoven, Ronald F.
    Nived, Ola
    Jonsen, Andreas
    Kamen, Diane L.
    Aranow, Cynthia
    Sanchez-Guerrero, Jorge
    Gladman, Dafna D.
    Fortin, Paul R.
    Alarcon, Graciela S.
    Merrill, Joan T.
    Kalunian, Kenneth
    Ramos-Casals, Manuel
    Steinsson, Kristjan
    Zoma, Asad
    Askanase, Anca
    Khamashta, Munther A.
    Bruce, Ian N.
    Inanc, Murat
    Abrahamowicz, Michal
    Bernatsky, Sasha
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (03) : 370 - 378
  • [2] Comment on the 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus by Fanouriakis et al
    Costedoat-Chalumeau, Nathalie
    Isenberg, David
    Petri, Michelle
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (08)
  • [3] A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self-Administered Questionnaires
    Costedoat-Chalumeau, Nathalie
    Houssiau, Frederic
    Izmirly, Peter
    Le Guern, Veronique
    Navarra, Sandra
    Jolly, Meenakshi
    Ruiz-Irastorza, Guillermo
    Baron, Gabriel
    Hachulla, Eric
    Agmon-Levin, Nancy
    Shoenfeld, Yehuda
    Dall'Ara, Francesca
    Buyon, Jill
    Deligny, Christophe
    Cervera, Ricard
    Lazaro, Estibaliz
    Bezanahary, Holy
    Leroux, Ga Elle
    Morel, Nathalie
    Viallard, Jean-Francois
    Pineau, Christian
    Galicier, Lionel
    Van Vollenhoven, Ronald
    Tincani, Angela
    Nguyen, Hanh
    Gondran, Guillaume
    Zahr, Noel
    Pouchot, Jacques
    Piette, Jean-Charles
    Petri, Michelle
    Isenberg, David
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 (06) : 1074 - 1082
  • [4] 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
    Fanouriakis, Antonis
    Kostopoulou, Myrto
    Alunno, Alessia
    Aringer, Martin
    Bajema, Ingeborg
    Boletis, John N.
    Cervera, Ricard
    Doria, Andrea
    Gordon, Caroline
    Govoni, Marcello
    Houssiau, Frederic
    Jayne, David
    Kouloumas, Marios
    Kuhn, Annegret
    Larsen, Janni L.
    Lerstrom, Kirsten
    Moroni, Gabriella
    Mosca, Marta
    Schneider, Matthias
    Smolen, Josef S.
    Svenungsson, Elisabet
    Tesar, Vladimir
    Tincani, Angela
    Troldborg, Anne
    van Vollenhoven, Ronald
    Wenzel, Joerg
    Bertsias, George
    Boumpas, Dimitrios T.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (06) : 736 - 745
  • [5] Dynamic patterns and predictors of hydroxychloroquine nonadherence among Medicaid beneficiaries with systemic lupus erythematosus
    Feldman, Candace H.
    Collins, Jamie
    Zhang, Zhi
    Subramanian, S. V.
    Solomon, Daniel H.
    Kawachi, Ichiro
    Costenbader, Karen H.
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2018, 48 (02) : 205 - 213
  • [6] Hydroxychloroquine Dose per Ophthalmology Guidelines and the Risk of Systemic Lupus Erythematosus Flares
    Jorge, April M.
    Mancini, Christian
    Zhou, Baijun
    Ho, Gary
    Zhang, Yuqing
    Costenbader, Karen
    Choi, Hyon K.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 328 (14): : 1458 - 1460
  • [7] Risk factors for hydroxychloroquine retinopathy in systemic lupus erythematosus: a case-control study with hydroxychloroquine blood-level analysis
    Lenfant, Tiphaine
    Salah, Sawsen
    Leroux, Gaelle
    Bousquet, Elodie
    Le Guern, Veronique
    Chasset, Francois
    Frances, Camille
    Morel, Nathalie
    Chezel, Julie
    Papo, Thomas
    Cacoub, Patrice
    Mouthon, Luc
    Guettrot-Imbert, Gaelle
    Cohen, Pascal
    Regent, Alexis
    Mauget-Faysse, Martine
    Piette, Jean-Charles
    Jallouli, Moez
    Costedoat-Chalumeau, Nathalie
    [J]. RHEUMATOLOGY, 2020, 59 (12) : 3807 - 3816
  • [8] Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision)
    Marmor, Michael F.
    Kellner, Ulrich
    Lai, Timothy Y. Y.
    Melles, Ronald B.
    Mieler, William F.
    [J]. OPHTHALMOLOGY, 2016, 123 (06) : 1386 - 1394
  • [9] Melles RB, 2014, JAMA OPHTHALMOL, V132, P1453, DOI 10.1001/jamaophthalmol.2014.3459
  • [10] Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus
    Petri, Michelle
    Konig, Maximilian F.
    Li, Jessica
    Goldman, Daniel W.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2021, 73 (06) : 997 - 1004
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