Neutrophils in aging and aging-related pathologies

被引：66

作者：

Van Avondt, Kristof ^{[1
]}

Strecker, Jan-Kolja ^{[2
]}

Tulotta, Claudia ^{[1
]}

Minnerup, Jens ^{[2
]}

Schulz, Christian ^{[3
,4
]}

Soehnlein, Oliver ^{[1
,5
]}

机构：

[1] Univ Munster, Ctr Mol Biol Inflammat ZMBE, Inst Expt Pathol ExPat, Munster, Germany

[2] Univ Hosp Munster, Inst Translat Neurol, Dept Neurol, Munster, Germany

[3] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 1, Munich, Germany

[4] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

[5] Karolinska Inst, Dept Physiol & Pharmacol FyFa, Stockholm, Sweden

来源：

IMMUNOLOGICAL REVIEWS | 2023年 / 314卷 / 01期

关键词：

neutrophil; aging; inflammation; stroke; myocardial infarction; cancer; HEMATOPOIETIC STEM-CELLS; STRESS PROMOTES ATHEROSCLEROSIS; EXTRACELLULAR TRAPS; CLONAL HEMATOPOIESIS; ADVANCED-AGE; RISK-FACTOR; GM-CSF; ACCELERATES ATHEROSCLEROSIS; PHOSPHOINOSITIDE; 3-KINASE; INFLAMMATORY RESPONSE;

D O I：

10.1111/imr.13153

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

引用

页码：357 / 375

页数：19

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