Neutrophils in aging and aging-related pathologies

被引：45
作者：
Van Avondt, Kristof [1 ]
Strecker, Jan-Kolja [2 ]
Tulotta, Claudia [1 ]
Minnerup, Jens [2 ]
Schulz, Christian [3 ,4 ]
Soehnlein, Oliver [1 ,5 ]
机构：
[1] Univ Munster, Ctr Mol Biol Inflammat ZMBE, Inst Expt Pathol ExPat, Munster, Germany
[2] Univ Hosp Munster, Inst Translat Neurol, Dept Neurol, Munster, Germany
[3] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 1, Munich, Germany
[4] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany
[5] Karolinska Inst, Dept Physiol & Pharmacol FyFa, Stockholm, Sweden
来源：
IMMUNOLOGICAL REVIEWS | 2023年 / 314卷 / 01期
关键词：
neutrophil; aging; inflammation; stroke; myocardial infarction; cancer; HEMATOPOIETIC STEM-CELLS; STRESS PROMOTES ATHEROSCLEROSIS; EXTRACELLULAR TRAPS; CLONAL HEMATOPOIESIS; ADVANCED-AGE; RISK-FACTOR; GM-CSF; ACCELERATES ATHEROSCLEROSIS; PHOSPHOINOSITIDE; 3-KINASE; INFLAMMATORY RESPONSE;
D O I：
10.1111/imr.13153
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.
引用
收藏
页码：357 / 375
页数：19
相关论文
共 268 条
  • [1] Chemokine signaling via the CXCR2 receptor reinforces senescence
    Acosta, Juan C.
    O'Loghlen, Ana
    Banito, Ana
    Guijarro, Maria V.
    Augert, Arnaud
    Raguz, Selina
    Fumagalli, Marzia
    Da Costa, Marco
    Brown, Celia
    Popov, Nikolay
    Takatsu, Yoshihiro
    Melamed, Jonathan
    di Fagagna, Fabrizio d'Adda
    Bernard, David
    Hernando, Eva
    Gil, Jesus
    [J]. CELL, 2008, 133 (06) : 1006 - 1018
  • [2] A Neutrophil Timer Coordinates Immune Defense and Vascular Protection
    Adrover, Jose M.
    del Fresno, Carlos
    Crainiciuc, Georgiana
    Isabel Cuartero, Maria
    Casanova-Acebes, Maria
    Weiss, Linnea A.
    Huerga-Encabo, Hector
    Silvestre-Roig, Carlos
    Rossaint, Jan
    Cossio, Itziar
    Lechuga-Vieco, Ana V.
    Garcia-Prieto, Jaime
    Gomez-Parrizas, Monica
    Quintana, Juan A.
    Ballesteros, Ivan
    Martin-Salamanca, Sandra
    Aroca-Crevillen, Alejandra
    Chong, Shu Zhen
    Evrard, Maximilien
    Balabanian, Karl
    Lopez, Jorge
    Bidzhekov, Kiril
    Bachelerie, Frangoise
    Abad-Santos, Francisco
    Munoz-Calleja, Cecilia
    Zarbock, Alexander
    Soehnlein, Oliver
    Weber, Christian
    Ng, Lai Guan
    Lopez-Rodriguez, Cristina
    Sancho, David
    Moro, Maria A.
    Ibanez, Borja
    Hidalgo, Andres
    [J]. IMMUNITY, 2019, 50 (02) : 390 - +
  • [3] Lessons in type 2 immunity: Neutrophils in Helminth infections
    Ajendra, Jesuthas
    [J]. SEMINARS IN IMMUNOLOGY, 2021, 53
  • [4] Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
    Alivernini, Stefano
    MacDonald, Lucy
    Elmesmari, Aziza
    Finlay, Samuel
    Tolusso, Barbara
    Gigante, Maria Rita
    Petricca, Luca
    Di Mario, Clara
    Bui, Laura
    Perniola, Simone
    Attar, Moustafa
    Gessi, Marco
    Fedele, Anna Laura
    Chilaka, Sabarinadh
    Somma, Domenico
    Sansom, Stephen N.
    Filer, Andrew
    McSharry, Charles
    Millar, Neal L.
    Kirschner, Kristina
    Nerviani, Alessandra
    Lewis, Myles J.
    Pitzalis, Costantino
    Clark, Andrew R.
    Ferraccioli, Gianfranco
    Udalova, Irina
    Buckley, Christopher D.
    Gremese, Elisa
    McInnes, Iain B.
    Otto, Thomas D.
    Kurowska-Stolarska, Mariola
    [J]. NATURE MEDICINE, 2020, 26 (08) : 1295 - +
  • [5] Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model
    Baik, Sung Hoon
    Cha, Moon-Yong
    Hyun, Young-Min
    Cho, Hansang
    Hamza, Bashar
    Kim, Dong Kyu
    Han, Sun-Ho
    Choi, Heesun
    Kim, Kyung Ho
    Moon, Minho
    Lee, Jeewoo
    Kim, Minsoo
    Irimia, Daniel
    Mook-Jung, Inhee
    [J]. NEUROBIOLOGY OF AGING, 2014, 35 (06) : 1286 - 1292
  • [6] Co-option of Neutrophil Fates by Tissue Environments
    Ballesteros, Ivan
    Rubio-Ponce, Andrea
    Genua, Marco
    Lusito, Eleonora
    Kwok, Immanuel
    Fernandez-Calvo, Gabriel
    Khoyratty, Tariq E.
    van Grinsven, Erinke
    Gonzalez-Hernandez, Sara
    Angel Nicolas-Avila, Jose
    Vicanolo, Tommaso
    Maccataio, Antonio
    Benguria, Alberto
    Li, Jackson LiangYao
    Adrover, Jose M.
    Aroca-Crevillen, Alejandra
    Quintana, Juan A.
    Martin-Salamanca, Sandra
    Mayo, Francisco
    Ascher, Stefanie
    Barbiera, Giulia
    Soehnlein, Oliver
    Gunzer, Matthias
    Ginhoux, Florent
    Sanchez-Cabo, Fatima
    Nistal-Villan, Estanislao
    Schulz, Christian
    Dopazo, Ana
    Reinhardt, Christoph
    Udalova, Irina A.
    Ng, Lai Guan
    Ostuni, Renato
    Hidalgo, Andres
    [J]. CELL, 2020, 183 (05) : 1282 - +
  • [7] Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
    Barkaway, Anna
    Rolas, Loic
    Joulia, Regis
    Bodkin, Jennifer
    Lenn, Tchern
    Owen-Woods, Charlotte
    Reglero-Real, Natalia
    Stein, Monja
    Vazquez-Martinez, Laura
    Girbl, Tamara
    Poston, Robin N.
    Golding, Matthew
    Saleeb, Rebecca S.
    Thiriot, Aude
    von Andrian, Ulrich H.
    Duchene, Johan
    Voisin, Mathieu-Benoit
    Bishop, Cleo L.
    Voehringer, David
    Roers, Axel
    Rot, Antal
    Laemmermann, Tim
    Nourshargh, Sussan
    [J]. IMMUNITY, 2021, 54 (07) : 1494 - +
  • [8] A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer's disease
    Bawa, Kritleen K.
    Krance, Saffire H.
    Herrmann, Nathan
    Cogo-Moreira, Hugo
    Ouk, Michael
    Yu, Di
    Wu, Che-Yuan
    Black, Sandra E.
    Lanctot, Krista L.
    Swardfager, Walter
    [J]. JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
  • [9] Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    Baxter, EJ
    Scott, LM
    Campbell, PJ
    East, C
    Fourouclas, N
    Swanton, S
    Vassiliou, GS
    Bench, AJ
    Boyd, EM
    Curtin, N
    Scott, MA
    Erber, WN
    Green, AR
    [J]. LANCET, 2005, 365 (9464) : 1054 - 1061
  • [10] Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury
    Beck-Schimmer, B
    Schwendener, R
    Pasch, T
    Reyes, L
    Booy, C
    Schimmer, RC
    [J]. RESPIRATORY RESEARCH, 2005, 6 (1):
12345678910