Inulin: Unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics

被引:15
作者
Akram, Wasim [1 ]
Pandey, Vikas [1 ]
Sharma, Rajeev [1 ]
Joshi, Ramakant [2 ]
Mishra, Neeraj [1 ]
Garud, Navneet [3 ]
Haider, Tanweer [1 ]
机构
[1] Amity Univ, Amity Inst Pharm, Dept Pharmaceut, Gwalior 4774005, Madhya Pradesh, India
[2] ShriRam Coll Pharm, Dept Pharmaceut, Banmore 476444, India
[3] Jiwaji Univ, Sch Studies Pharmaceut Sci, Gwalior 474011, India
关键词
Inulin; Prebiotics; Probiotics; Drug delivery; Therapeutics; Biopolymers; HUMAN COLONIC MICROBIOTA; CHAIN FATTY-ACIDS; IN-VITRO; TARGETED DELIVERY; GUT MICROBIOTA; DELTA-INULIN; CARDIOVASCULAR-DISEASE; DOXORUBICIN CONJUGATE; JERUSALEM-ARTICHOKE; DIETARY MODULATION;
D O I
10.1016/j.ijbiomac.2023.129131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years, inulin has gained much attention as a promising multifunctional natural biopolymer with numerous applications in drug delivery, prebiotics, and therapeutics. It reveals a multifaceted biopolymer with transformative implications by elucidating the intricate interplay between inulin and the host, microbiome, and therapeutic agents. Their flexible structure, exceptional targetability, biocompatibility, inherent ability to control release behavior, tunable degradation kinetics, and protective ability make them outstanding carriers in healthcare and biomedicine. USFDA has approved Inulin as a nutritional dietary supplement for infants. The possible applications of inulin in biomedicine research inspired by nature are presented. The therapeutic potential of inulin goes beyond its role in prebiotics and drug delivery. Recently, significant research efforts have been made towards inulin's anti-inflammatory, antioxidant, and immunomodulatory properties for their potential applications in treating various chronic diseases. Moreover, its ability to reduce inflammation and modulate immune responses opens new avenues for treating conditions such as autoimmune disorders and gastrointestinal ailments. This review will attempt to illustrate the inulin's numerous and interconnected roles, shedding light on its critical contributions to the advancement of healthcare and biomedicine and its recent advancement in therapeutics, and conclude by taking valuable insights into the prospects and opportunities of inulin.
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页数:17
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