Highly photoactive Ir(<sc>iii</sc>)-Pt(<sc>iv</sc>) heterometallic conjugates for anticancer therapy

被引：2

作者：

Hu, Wangman ^{[1
]}

Liu, Rongzhi ^{[1
]}

Zheng, Kai ^{[1
]}

Wang, Zhigang ^{[1
]}

机构：

[1] Shenzhen Univ, Int Canc Ctr, Sch Pharm, Nation Reg Engn Lab Synthet Biol Med,Med Sch, Shenzhen 518060, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 04期

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; COMPLEXES; AGENTS;

D O I：

10.1039/d3cc04938h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the first time, this study reported the photoactivatable activity of Ir(iii)-Pt(iv) heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin and Ir within 3 min of irradiation. The conjugates induced apoptosis and immunologic cell death through Pt-DNA binding and reactive oxygen species generation upon irradiation. This work developed photoactivatable heterometallic agents for anticancer therapy.

引用

页码：388 / 391

页数：5

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