2-(Sulfanylmethyl)indol-3-yl Acetic Acid Derivatives: Synthesis and In Silico Prediction of Anti-Inflammatory Activity

被引：1
作者：
Akhmetova, V. R. [1 ]
Leont'ev, D. V. [1 ]
Akhmadiev, N. S. [1 ]
Khairullina, V. R. [2 ]
机构：
[1] Russian Acad Sci, Inst Petrochemistry & Catalysis, Ufa Fed Res Ctr, Ufa 450075, Russia
[2] Ufa Univ Sci & Technol, Ufa 450076, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / SUPPL 1期
关键词：
sulfanylmethyl derivative of indol-3-yl-acetic acid; pyrazole; anti-inflammatory activity; molecular docking; cyclooxygenases; DOCKING;
D O I：
10.1134/S1070363223140190
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
{2-[(2-Hydroxyethyl)sulfanylmethyl]indol-3-yl}acetic ester and hydrazide were synthesized for use in the directed synthesis of {2-[(2-hydroxyethyl)sulfanylmethyl]indol-3-yl}acetic acid-derived pyrazole. Predictive analysis and in silico calculations of the bioavailability, potential toxicity, and anti-inflammatory activity of the synthesized compounds were carried out by molecular docking assessment of their inhibitory activity against cyclooxygenases.
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收藏
页码：S106 / S114
页数：9
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