The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

被引：41

作者：

Al-kuraishy, Haydar M. ^{[1
]}

Jabir, Majid S. ^{[2
]}

Albuhadily, Ali K. ^{[1
]}

Al-Gareeb, Ali I. ^{[1
]}

Rafeeq, Mayyadah F. ^{[2
]}

机构：

[1] Mustansiriyah Univ, Coll Med, Dept Clin pharmacol & Med, Baghdad, Iraq

[2] Technol Univ, Dept Appl Sci, Baghdad, Iraq

来源：

AGEING RESEARCH REVIEWS | 2023年 / 91卷

关键词：

Metabolic syndrome; Alzheimer disease; Amyloid beta; Insulin resistance; Obesity; Hypertension; BRAIN INSULIN-RESISTANCE; AMYLOID-BETA-PROTEIN; NF-KAPPA-B; DIABETES-MELLITUS; OXIDATIVE STRESS; A-BETA; RISK-FACTOR; INFLAMMATION; ACID; PATHOGENESIS;

D O I：

10.1016/j.arr.2023.102084

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease (AD) neuropathology. Components of MetS including central obesity, hypertension, insulin resistance (IR), and dyslipidemia adversely affect the pathogenesis of AD by different mechanisms including activation of renin-angiotensin system (RAS), inflammatory signaling pathways, neuroinflammation, brain IR, mitochondrial dysfunction, and oxidative stress. MetS exacerbates AD neuropathology, and targeting of molecular pathways in MetS by pharmacological approach could a novel therapeutic strategy in the management of AD in high risk group. However, the underlying mechanisms of these pathways in AD neuropathology are not completely clarified. Therefore, this review aims to elucidate the association between MetS and AD regarding the oxidative and inflammatory mechanistic pathways.

引用

页数：10

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