Simultaneous high-resolution whole-brain MR spectroscopy and [18F]FDG PET for temporal lobe epilepsy

被引:0
作者
Huang, Hui [1 ]
Zhang, Miao [2 ]
Zhao, Yibo [3 ,4 ]
Li, Yudu [3 ,5 ]
Jin, Wen [3 ,4 ]
Guo, Rong [3 ,6 ]
Liu, Wei [7 ]
Cai, Bingyang [1 ]
Li, Jiwei [1 ]
Yuan, Siyu [1 ]
Huang, Xinyun [2 ]
Lin, Xiaozhu [2 ]
Liang, Zhi-Pei [3 ,4 ]
Li, Biao [2 ]
Luo, Jie [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Nucl Med, Sch Med, Shanghai 200025, Peoples R China
[3] Univ Illinois Urbana & Champaign, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA
[5] Univ Illinois, Natl Ctr Supercomp Applicat, Urbana, IL 61801 USA
[6] Siemens Med Solut USA Inc, Urbana, IL 61801 USA
[7] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurosurg, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
PET/MRSI; N-Acetyl aspartate; Glucose; Temporal lobe epilepsy; Lateralization; N-ACETYLASPARTATE; RESONANCE SPECTROSCOPY; HIPPOCAMPAL SCLEROSIS; PILOCARPINE MODEL; NEGATIVE-PATIENTS; SUBSPACE APPROACH; NETWORK; ABNORMALITIES; F-18-FDG-PET; ACQUISITION;
D O I
10.1007/s00259-023-06465-0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose Precise lateralizing the epileptogenic zone in patients with drug-resistant mesial temporal lobe epilepsy (mTLE) remains challenging, particularly when routine MRI scans are inconclusive (MRI-negative). This study aimed to investigate the synergy of fast, high-resolution, whole-brain MRSI in conjunction with simultaneous [F-18]FDG PET for the lateralization of mTLE.Methods Forty-eight drug-resistant mTLE patients (M/F 31/17, age 12-58) underwent MRSI and [F-18]FDG PET on a hybrid PET/MR scanner. Lateralization of mTLE was evaluated by visual inspection and statistical classifiers of metabolic mappings against routine MRI. Additionally, this study explored how disease status influences the associations between altered N-acetyl aspartate (NAA) and FDG uptake using hierarchical moderated multiple regression.Results The high-resolution whole-brain MRSI data offers metabolite maps at comparable resolution to [F-18]FDG PET. Visual examinations of combined MRSI and [F-18]FDG PET showed an mTLE lateralization accuracy rate of 91.7% in a 48-patient cohort, surpassing routine MRI (52.1%). Notably, out of 23 MRI-negative mTLE, combined MRSI and [F-18]FDG PET helped detect 19 cases. Logistical regression models combining hippocampal NAA level and FDG uptake improved lateralization performance (AUC=0.856), while further incorporating extrahippocampal regions such as amygdala, thalamus, and superior temporal gyrus increased the AUC to 0.939. Concurrent MRSI/PET revealed a moderating influence of disease duration and hippocampal atrophy on the association between hippocampal NAA and glucose uptake, providing significant new insights into the disease's trajectory.Conclusion This paper reports the first metabolic imaging study using simultaneous high-resolution MRSI and [F-18]FDG PET, which help visualize MRI-unidentifiable lesions and may thus advance diagnostic tools and management strategies for drug-resistant mTLE.
引用
收藏
页码:721 / 733
页数:13
相关论文
共 71 条
[1]   Best-practice recommendations for estimating interaction effects using moderated multiple regression [J].
Aguinis, Herman ;
Gottfredson, Ryan K. .
JOURNAL OF ORGANIZATIONAL BEHAVIOR, 2010, 31 (06) :776-786
[2]   History of the Network Approach in Epilepsy Surgery [J].
Amorim-Leite, Ricardo ;
Remick, Madison ;
Welch, William ;
Abel, Taylor J. .
NEUROSURGERY CLINICS OF NORTH AMERICA, 2020, 31 (03) :301-+
[3]   Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis [J].
Aparicio, Javier ;
Carreno, Mar ;
Bargallo, Nuria ;
Setoain, Xavier ;
Rubi, Sebastia ;
Rumia, Jordi ;
Falcon, Carles ;
Calvo, Anna ;
Marti-Fuster, Berta ;
Padilla, Nelly ;
Boget, Teresa ;
Pintor, Luis ;
Donaire, Antonio .
NEUROIMAGE-CLINICAL, 2016, 12 :976-989
[4]   Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG [J].
Bartolomei, Fabrice ;
Chauvel, Patrick ;
Wendling, Fabrice .
BRAIN, 2008, 131 :1818-1830
[5]   International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods [J].
Bluemcke, Ingmar ;
Thom, Maria ;
Aronica, Eleonora ;
Armstrong, Dawna D. ;
Bartolomei, Fabrice ;
Bernasconi, Andrea ;
Bernasconi, Neda ;
Bien, Christian G. ;
Cendes, Fernando ;
Coras, Roland ;
Cross, J. Helen ;
Jacques, Thomas S. ;
Kahane, Philippe ;
Mathern, Gary W. ;
Miyata, Haijme ;
Moshe, Solomon L. ;
Oz, Buge ;
Oezkara, Cigdem ;
Perucca, Emilio ;
Sisodiya, Sanjay ;
Wiebe, Samuel ;
Spreafico, Roberto .
EPILEPSIA, 2013, 54 (07) :1315-1329
[6]   Standards for PET Image Acquisition and Quantitative Data Analysis [J].
Boellaard, Ronald .
JOURNAL OF NUCLEAR MEDICINE, 2009, 50 :11S-20S
[7]  
Capizzano AA, 2002, AM J NEURORADIOL, V23, P1359
[8]   MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome [J].
Carne, RP ;
O'Brien, TJ ;
Kilpatrick, CJ ;
MacGregor, LR ;
Hicks, RJ ;
Murphy, MA ;
Bowden, SC ;
Kaye, AH ;
Cook, MJ .
BRAIN, 2004, 127 :2276-2285
[9]   LATERALIZATION OF TEMPORAL-LOBE EPILEPSY BASED ON REGIONAL METABOLIC ABNORMALITIES IN PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGES [J].
CENDES, F ;
ANDERMANN, F ;
PREUL, MC ;
ARNOLD, DL .
ANNALS OF NEUROLOGY, 1994, 35 (02) :211-216
[10]   N-acetylaspartate as a reservoir for glutamate [J].
Clark, Joseph F. ;
Doepke, Amos ;
Filosa, Jessica A. ;
Wardle, Robert L. ;
Lu, Aigang ;
Meeker, Timothy J. ;
Pyne-Geithman, Gail J. .
MEDICAL HYPOTHESES, 2006, 67 (03) :506-512