Current Advances in the Biosynthesis, Metabolism, and Transcriptional Regulation of α-Tomatine in Tomato

被引:3
作者
Liu, Yuanyuan [1 ,2 ]
Hu, Hanru [1 ]
Yang, Rujia [1 ]
Zhu, Zhujun [1 ]
Cheng, Kejun [2 ]
机构
[1] Zhejiang A&F Univ, Coll Hort Sci,Minist Agr & Rural Affairs, Collaborat Innovat Ctr Efficient & Green Prod Agr, Key Lab Qual & Safety Control Subtrop Fruit & Vege, Hangzhou 311300, Peoples R China
[2] Lishui Inst Agr & Forestry Sci, Chem Biol Ctr, Lishui 323000, Peoples R China
来源
PLANTS-BASEL | 2023年 / 12卷 / 18期
基金
中国国家自然科学基金;
关键词
tomato; alpha-tomatine; biosynthesis; metabolism; transcriptional regulation; biological activity; STEROIDAL GLYCOALKALOIDS; ETHYLENE; EXPRESSION; INVOLVEMENT; ALKALOIDS; PATHWAY; PLANT;
D O I
10.3390/plants12183289
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Steroid glycoalkaloids (SGAs) are a class of cholesterol-derived metabolites commonly found in the Solanaceae plants. alpha-Tomatine, a well-known bitter-tasting compound, is the major SGA in tomato, accumulating extensively in all plant tissues, particularly in the leaves and immature green fruits. alpha-Tomatine exhibits diverse biological activities that contribute to plant defense against pathogens and herbivores, as well as conferring certain medicinal benefits for human health. This review summarizes the current knowledge on alpha-tomatine, including its molecular chemical structure, physical and chemical properties, biosynthetic and metabolic pathways, and transcriptional regulatory mechanisms. Moreover, potential future research directions and applications of alpha-tomatine are also discussed.
引用
收藏
页数:13
相关论文
共 46 条
  • [1] Jasmonate-induced biosynthesis of steroidal glycoalkaloids depends on COI1 proteins in tomato
    Abdelkareem, Ayman
    Thagun, Chonprakun
    Nakayasu, Masaru
    Mizutani, Masaharu
    Hashimoto, Takashi
    Shoji, Tsubasa
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 489 (02) : 206 - 210
  • [2] Tomato E8 Encodes a C-27 Hydroxylase in Metabolic Detoxification of α-Tomatine during Fruit Ripening
    Akiyama, Ryota
    Nakayasu, Masaru
    Umemoto, Naoyuki
    Kato, Junpei
    Kobayashi, Midori
    Lee, Hyoung Jae
    Sugimoto, Yukihiro
    Iijima, Yoko
    Saito, Kazuki
    Muranaka, Toshiya
    Mizutani, Masaharu
    [J]. PLANT AND CELL PHYSIOLOGY, 2021, 62 (05) : 775 - 783
  • [3] Characterization of steroid 5α-reductase involved in α-tomatine biosynthesis in tomatoes
    Akiyama, Ryota
    Lee, Hyoung Jae
    Nakayasu, Masaru
    Osakabe, Keishi
    Osakabe, Yuriko
    Umemoto, Naoyuki
    Saito, Kazuki
    Muranaka, Toshiya
    Sugimoto, Yukihiro
    Mizutani, Masaharu
    [J]. PLANT BIOTECHNOLOGY, 2019, 36 (04) : 253 - 263
  • [4] Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
    Cardenas, Pablo D.
    Sonawane, Prashant D.
    Heinig, Uwe
    Jozwiak, Adam
    Panda, Sayantan
    Abebie, Bekele
    Kazachkova, Yana
    Pliner, Margarita
    Unger, Tamar
    Wolf, Dalia
    Ofner, Itai
    Vilaprinyo, Ester
    Meir, Sagit
    Davydov, Olga
    Gal-On, Amit
    Burdman, Saul
    Giri, Ashok
    Zamir, Dani
    Scherf, Tali
    Szymanski, Jedrzej
    Rogachev, Ilana
    Aharoni, Asaph
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [5] GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway
    Cardenas, Pablo D.
    Sonawane, Prashant D.
    Pollier, Jacob
    Vanden Bossche, Robin
    Dewangan, Veena
    Weithorn, Efrat
    Tal, Lior
    Meir, Sagit
    Rogachev, Ilana
    Malitsky, Sergey
    Giri, Ashok P.
    Goossens, Alain
    Burdman, Saul
    Aharoni, Asaph
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [6] Solanum lycopersicum microRNA1916 targets multiple target genes and negatively regulates the immune response in tomato
    Chen, Lei
    Meng, Jun
    He, Xiao Li
    Zhang, Min
    Luan, Yu Shi
    [J]. PLANT CELL AND ENVIRONMENT, 2019, 42 (04) : 1393 - 1407
  • [7] Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate
    Clark, Shawn M.
    Di Leo, Rosa
    Van Cauwenberghe, Owen R.
    Mullen, Robert T.
    Shelp, Barry J.
    [J]. JOURNAL OF EXPERIMENTAL BOTANY, 2009, 60 (11) : 3255 - 3267
  • [8] Computational note on the calculation of the dipole moment, polarizability and hyperpolarizability of solanidine
    Flores-Holguin, Norma
    Rodriguez-Valdez, Luz Maria
    Glossman-Mitnik, Daniel
    [J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2008, 849 (1-3): : 122 - 123
  • [9] Tomato glycoalkaloids: Role in the plant and in the diet
    Friedman, M
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (21) : 5751 - 5780
  • [10] Potato glycoalkaloids and metabolites: Roles in the plant and in the diet
    Friedman, Mendel
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (23) : 8655 - 8681