Synthesis of 2-amino-4-aryl-6-styrylpyrimidines through aza-Michael addition/nucleophilic addition/dehydrogenation cascade reactions

被引：1

作者：

Wang, Yue ^{[1
]}

Li, Zheng ^{[1
,2
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China

[2] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 12期

基金：

中国国家自然科学基金;

关键词：

VARIOLIN-B; 3-COMPONENT REACTION; DERIVATIVES; EFFICIENT; 2-AMINOPYRIMIDINES; QUINAZOLINE; PYRIMIDINES; MINOXIDIL; BUSPIRONE;

D O I：

10.1002/jhet.4731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of 2-amino-4-aryl-6-styrylpyrimidines by the reactions of various distyryl ketones with guanidine hydrochloride through aza-Michael addition/nucleophilic addition/dehydrogenation cascade processes is described. The salient features of this protocol are the use of easy-to-obtain substrates, transition-metal-free system, mild reaction conditions, high atom economy, wide substrate scope, satisfactory yield, and simple work-up procedures.

引用

页码：1999 / 2008

页数：10

共 43 条

[41] Copper-catalyzed three-component formal [3+1+2] annulations for the synthesis of 2-aminopyrimidines from O-acyl ketoximes
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[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 19 (40) : 8706 - 8710
[42] Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction
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[43] Efficient and Facile Three-Component Reaction for the Synthesis of 2-Amine-4,6-diarylpyrimidine Under Solvent-Free Conditions
Zhuang, Qiya
Han, HongXia
Wang, Suhui
Tu, Shuajiang
Rong, Liangce
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