Synthesis of 2-amino-4-aryl-6-styrylpyrimidines through aza-Michael addition/nucleophilic addition/dehydrogenation cascade reactions

被引：1
作者：
Wang, Yue [1 ]
Li, Zheng [1 ,2 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China
[2] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 12期
基金：
中国国家自然科学基金;
关键词：
VARIOLIN-B; 3-COMPONENT REACTION; DERIVATIVES; EFFICIENT; 2-AMINOPYRIMIDINES; QUINAZOLINE; PYRIMIDINES; MINOXIDIL; BUSPIRONE;
D O I：
10.1002/jhet.4731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of 2-amino-4-aryl-6-styrylpyrimidines by the reactions of various distyryl ketones with guanidine hydrochloride through aza-Michael addition/nucleophilic addition/dehydrogenation cascade processes is described. The salient features of this protocol are the use of easy-to-obtain substrates, transition-metal-free system, mild reaction conditions, high atom economy, wide substrate scope, satisfactory yield, and simple work-up procedures.
引用
收藏
页码：1999 / 2008
页数：10
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