Enhancer Function in the 3D Genome

被引：5
作者：
Razin, Sergey V. [1 ,2 ]
Ulianov, Sergey V. [1 ,2 ]
Iarovaia, Olga V. [1 ]
机构：
[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia
[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119234, Russia
来源：
GENES | 2023年 / 14卷 / 06期
关键词：
enhancer-promoter communication; 3D genome; chromatin compartment; phase separation; BETA-GLOBIN GENE; PROMOTER COMMUNICATION; ACTIVE CHROMATIN; TRANSCRIPTIONAL REGULATION; REGULATORY REGIONS; SINGLE-CELL; LONG; EXPRESSION; DOMAINS; COHESIN;
D O I：
10.3390/genes14061277
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed.
引用
收藏
页数：15
相关论文
共 156 条
  • [81] Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
    Lee, Joo-Hyung
    Wang, Ruoyu
    Xiong, Feng
    Krakowiak, Joanna
    Liao, Zian
    Nguyen, Phuoc T.
    Moroz-Omori, Elena V.
    Shao, Jiaofang
    Zhu, Xiaoyu
    Bolt, Michael J.
    Wu, Haoyi
    Singh, Pankaj K.
    Bi, Mingjun
    Shi, Caleb J.
    Jamal, Naadir
    Li, Guojie
    Mistry, Ragini
    Jung, Sung Yun
    Tsai, Kuang-Lei
    Ferreon, Josephine C.
    Stossi, Fabio
    Caflisch, Amedeo
    Liu, Zhijie
    Mancini, Michael A.
    Li, Wenbo
    [J]. MOLECULAR CELL, 2021, 81 (16) : 3368 - +
  • [82] A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly
    Lettice, LA
    Heaney, SJH
    Purdie, LA
    Li, L
    de Beer, P
    Oostra, BA
    Goode, D
    Elgar, G
    Hill, RE
    de Graaff, E
    [J]. HUMAN MOLECULAR GENETICS, 2003, 12 (14) : 1725 - 1735
  • [83] Transcriptional control by enhancers and enhancer RNAs
    Lewis, Michael W.
    Li, Shen
    Franco, Hector L.
    [J]. TRANSCRIPTION-AUSTIN, 2019, 10 (4-5): : 171 - 186
  • [84] Single-gene imaging links genome topology, promoter-enhancer communication and transcription control
    Li, Jieru
    Hsu, Angela
    Hua, Yujing
    Wang, Guanshi
    Cheng, Lingling
    Ochiai, Hiroshi
    Yamamoto, Takashi
    Pertsinidis, Alexandros
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 27 (11) : 1032 - +
  • [85] Locus control regions
    Li, QL
    Peterson, KR
    Fang, XD
    Stamatoyannopoulos, G
    [J]. BLOOD, 2002, 100 (09) : 3077 - 3086
  • [86] Nuclear Protein Condensates and Their Properties in Regulation of Gene Expression
    Li, Wei
    Jiang, Hao
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2022, 434 (01)
  • [87] Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
    Li, Wenbo
    Notani, Dimple
    Ma, Qi
    Tanasa, Bogdan
    Nunez, Esperanza
    Chen, Aaron Yun
    Merkurjev, Daria
    Zhang, Jie
    Ohgi, Kenneth
    Song, Xiaoyuan
    Oh, Soohwan
    Kim, Hong-Sook
    Glass, Christopher K.
    Rosenfeld, Michael G.
    [J]. NATURE, 2013, 498 (7455) : 516 - +
  • [88] Deep generative modeling and clustering of single cell Hi -C data
    Liu, Qiao
    Zengt, Wanwen
    Zhang, Wei
    Wang, Sicheng
    Chen, Hongyang
    Jiang, Rui
    Zhou, Mu
    Zhang, Shaoting
    [J]. BRIEFINGS IN BIOINFORMATICS, 2023, 24 (01)
  • [89] Breaking TADs: How Alterations of Chromatin Domains Result in Disease
    Lupianez, Dario G.
    Spielmann, Malte
    Mundlos, Stefan
    [J]. TRENDS IN GENETICS, 2016, 32 (04) : 225 - 237
  • [90] Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
    Lupianez, Dario G.
    Kraft, Katerina
    Heinrich, Verena
    Krawitz, Peter
    Brancati, Francesco
    Klopocki, Eva
    Hom, Denise
    Kayserili, Hulya
    Opitz, John M.
    Laxova, Renata
    Santos-Simarro, Fernando
    Gilbert-Dussardier, Brigitte
    Wittler, Lars
    Borschiwer, Marina
    Haas, Stefan A.
    Osterwalder, Marco
    Franke, Martin
    Timmermann, Bernd
    Hecht, Jochen
    Spielmann, Malte
    Visel, Axel
    Mundlos, Stefan
    [J]. CELL, 2015, 161 (05) : 1012 - 1025
45678910111213