Enhancer Function in the 3D Genome

被引：5
作者：
Razin, Sergey V. [1 ,2 ]
Ulianov, Sergey V. [1 ,2 ]
Iarovaia, Olga V. [1 ]
机构：
[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia
[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119234, Russia
来源：
GENES | 2023年 / 14卷 / 06期
关键词：
enhancer-promoter communication; 3D genome; chromatin compartment; phase separation; BETA-GLOBIN GENE; PROMOTER COMMUNICATION; ACTIVE CHROMATIN; TRANSCRIPTIONAL REGULATION; REGULATORY REGIONS; SINGLE-CELL; LONG; EXPRESSION; DOMAINS; COHESIN;
D O I：
10.3390/genes14061277
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed.
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页数：15
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