Enhancer Function in the 3D Genome

被引：5
作者：
Razin, Sergey V. [1 ,2 ]
Ulianov, Sergey V. [1 ,2 ]
Iarovaia, Olga V. [1 ]
机构：
[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia
[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119234, Russia
来源：
GENES | 2023年 / 14卷 / 06期
关键词：
enhancer-promoter communication; 3D genome; chromatin compartment; phase separation; BETA-GLOBIN GENE; PROMOTER COMMUNICATION; ACTIVE CHROMATIN; TRANSCRIPTIONAL REGULATION; REGULATORY REGIONS; SINGLE-CELL; LONG; EXPRESSION; DOMAINS; COHESIN;
D O I：
10.3390/genes14061277
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed.
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页数：15
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共 156 条
  • [1] Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
    Alexander, Jeffrey M.
    Guan, Juan
    Li, Bingkun
    Maliskova, Lenka
    Song, Michael
    Shen, Yin
    Huang, Bo
    Lomvardas, Stavros
    Weiner, Orion D.
    [J]. ELIFE, 2019, 8
  • [2] Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF
    Aljahani, Abrar
    Hua, Peng
    Karpinska, Magdalena A.
    Quililan, Kimberly
    Davies, James O. J.
    Oudelaar, A. Marieke
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
  • [3] Determinants of enhancer and promoter activities of regulatory elements
    Andersson, Robin
    Sandelin, Albin
    [J]. NATURE REVIEWS GENETICS, 2020, 21 (02) : 71 - 87
  • [4] Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model
    Andersson, Robin
    [J]. BIOESSAYS, 2015, 37 (03) : 314 - 323
  • [5] Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
    Arnold, Preston R.
    Wells, Andrew D.
    Li, Xian C.
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 7
  • [6] Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
    Arnosti, DN
    Kulkarni, MM
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 94 (05) : 890 - 898
  • [7] EXPRESSION OF A BETA-GLOBIN GENE IS ENHANCED BY REMOTE SV40 DNA-SEQUENCES
    BANERJI, J
    RUSCONI, S
    SCHAFFNER, W
    [J]. CELL, 1981, 27 (02) : 299 - 308
  • [8] Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping
    Bartman, Caroline R.
    Hsu, Sarah C.
    Hsiung, Chris C. -S.
    Raj, Arjun
    Blobel, Gerd A.
    [J]. MOLECULAR CELL, 2016, 62 (02) : 237 - 247
  • [9] Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes
    Beliveau, Brian J.
    Boettiger, Alistair N.
    Avendano, Maier S.
    Jungmann, Ralf
    McCole, Ruth B.
    Joyce, Eric F.
    Kim-Kiselak, Caroline
    Bantignies, Frederic
    Fonseka, Chamith Y.
    Erceg, Jelena
    Hannan, Mohammed A.
    Hoang, Hien G.
    Colognori, David
    Lee, Jeannie T.
    Shih, William M.
    Yin, Peng
    Zhuang, Xiaowei
    Wu, Chao-ting
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [10] Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation
    Benabdallah, Nezha S.
    Williamson, Iain
    Illingworth, Robert S.
    Kane, Lauren
    Boyle, Shelagh
    Sengupta, Dipta
    Grimes, Graeme R.
    Therizols, Pierre
    Bickmore, Wendy A.
    [J]. MOLECULAR CELL, 2019, 76 (03) : 473 - +
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