JMJD3 Exerts Oncorepressor Activity in Acute Promyelocytic Leukemia by Promoting PU.1 Expression

被引：0
作者：
Wang, Meng-Xi [1 ,2 ]
Yu, Shan-He [1 ]
Xiao, Min [3 ]
Chen, Juan [1 ]
机构：
[1] Shanghai Jiao Tong Univ Sch Med, Ruijin Hosp, Shanghai Inst Hematol, Natl Res Ctr Translat Med Shanghai, Shanghai 200025, Peoples R China
[2] Xuzhou Med Univ, Xuzhou Cent Hosp, Dept Hematol, Xuzhou 221009, Peoples R China
[3] Fudan Univ, Obstet & Gynecol Hosp, Shanghai Ji Ai Genet & IVF Inst, Shanghai 200011, Peoples R China
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 04期
基金：
中国国家自然科学基金;
关键词：
acute myeloid leukemia; histone demethylase; JMJD3; PU; 1; myeloid differentiation; ACUTE MYELOID-LEUKEMIA; GENE-EXPRESSION; DIFFERENTIATION; MACROPHAGE;
D O I：
10.1134/S0026893323040179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
All-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL) has been the most famous differentiation induction therapy during which the expression of PU.1, a key transcription factor (TF) for myeloid lineage determination in normal hematopoiesis is restored. In our previous studies, we found a stress-inducible H3K27 demethylase, JMJD3, to directly upregulate PU.1 expression to promote myeloid commitment during normal myelopoiesis. In addition, JMJD3 acts as an oncorepressor and plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. In this study, we further resolved the relationship between JMJD3 and PU.1 in APL therein JMJD3 exerts oncorepressor activity via promoting PU.1 expression.
引用
收藏
页码：653 / 660
页数：8
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