JMJD3 Exerts Oncorepressor Activity in Acute Promyelocytic Leukemia by Promoting PU.1 Expression

被引：0
作者：
Wang, Meng-Xi [1 ,2 ]
Yu, Shan-He [1 ]
Xiao, Min [3 ]
Chen, Juan [1 ]
机构：
[1] Shanghai Jiao Tong Univ Sch Med, Ruijin Hosp, Shanghai Inst Hematol, Natl Res Ctr Translat Med Shanghai, Shanghai 200025, Peoples R China
[2] Xuzhou Med Univ, Xuzhou Cent Hosp, Dept Hematol, Xuzhou 221009, Peoples R China
[3] Fudan Univ, Obstet & Gynecol Hosp, Shanghai Ji Ai Genet & IVF Inst, Shanghai 200011, Peoples R China
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 04期
基金：
中国国家自然科学基金;
关键词：
acute myeloid leukemia; histone demethylase; JMJD3; PU; 1; myeloid differentiation; ACUTE MYELOID-LEUKEMIA; GENE-EXPRESSION; DIFFERENTIATION; MACROPHAGE;
D O I：
10.1134/S0026893323040179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
All-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL) has been the most famous differentiation induction therapy during which the expression of PU.1, a key transcription factor (TF) for myeloid lineage determination in normal hematopoiesis is restored. In our previous studies, we found a stress-inducible H3K27 demethylase, JMJD3, to directly upregulate PU.1 expression to promote myeloid commitment during normal myelopoiesis. In addition, JMJD3 acts as an oncorepressor and plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. In this study, we further resolved the relationship between JMJD3 and PU.1 in APL therein JMJD3 exerts oncorepressor activity via promoting PU.1 expression.
引用
收藏
页码：653 / 660
页数：8
相关论文
共 32 条
[1]   A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network [J].
Anguita, Eduardo ;
Gupta, Rajeev ;
Olariu, Victor ;
Valk, Peter J. ;
Peterson, Carsten ;
Delwel, Ruud ;
Enver, Tariq .
DEVELOPMENTAL BIOLOGY, 2016, 411 (02) :277-286
[2]   KDM1 Class Flavin-Dependent Protein Lysine Demethylases [J].
Burg, Jonathan M. ;
Link, Jennifer E. ;
Morgan, Brittany S. ;
Heller, Frederick J. ;
Hargrove, Amanda E. ;
McCafferty, Dewey G. .
BIOPOLYMERS, 2015, 104 (04) :213-246
[3]   The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation [J].
Chen, Shuzhen ;
Ma, Jian ;
Wu, Feizhen ;
Xiong, Li-jun ;
Ma, Honghui ;
Xu, Wenqi ;
Lv, Ruitu ;
Li, Xiaodong ;
Villen, Judit ;
Gygi, Steven P. ;
Liu, Xiaole Shirley ;
Shi, Yang .
GENES & DEVELOPMENT, 2012, 26 (12) :1364-1375
[4]   Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBP ratio and granulocyte colony-stimulating factor [J].
Dahl, R ;
Walsh, JC ;
Lancki, D ;
Laslo, P ;
Iyer, SR ;
Singh, H ;
Simon, MC .
NATURE IMMUNOLOGY, 2003, 4 (10) :1029-1036
[5]   Regulation of B lymphocyte and macrophage development by graded expression of PU.1 [J].
DeKoter, RP ;
Singh, H .
SCIENCE, 2000, 288 (5470) :1439-1441
[6]   C/EBPβ:: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells [J].
Duprez, E ;
Wagner, K ;
Koch, H ;
Tenen, DG .
EMBO JOURNAL, 2003, 22 (21) :5806-5816
[7]   Role of PU.1 in hematopoiesis [J].
Fisher, RC ;
Scott, EW .
STEM CELLS, 1998, 16 (01) :25-37
[8]   G-CSF upregulates the expression of aquaporin-9 through CEBPB to enhance the cytotoxic activity of arsenic trioxide to acute myeloid leukemia cells [J].
Fu, Wanbin ;
Zhu, Gelan ;
Xu, Lan ;
Liu, Jia ;
Han, Xiaofeng ;
Wang, Junying ;
Wang, Xinpeng ;
Hou, Jian ;
Zhao, Huanbin ;
Zhong, Hua .
CANCER CELL INTERNATIONAL, 2022, 22 (01)
[9]   Development of Monocytes, Macrophages, and Dendritic Cells [J].
Geissmann, Frederic ;
Manz, Markus G. ;
Jung, Steffen ;
Sieweke, Michael H. ;
Merad, Miriam ;
Ley, Klaus .
SCIENCE, 2010, 327 (5966) :656-661
[10]   Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia [J].
Gutéerrez, NC ;
López-Pérez, R ;
Hernández, JM ;
Isidro, I ;
González, B ;
Delgado, M ;
Fermiñan, E ;
García, JL ;
Vázquez, L ;
González, M ;
San Miguel, JF .
LEUKEMIA, 2005, 19 (03) :402-409
1234