DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation

被引：31

作者：

Jokai, Matyas ^{[1
]}

Torma, Ferenc ^{[1
,2
,3
]}

McGreevy, Kristen M. M. ^{[4
]}

Koltai, Erika ^{[1
]}

Bori, Zoltan ^{[1
]}

Babszki, Gergely ^{[1
]}

Bakonyi, Peter ^{[1
]}

Gombos, Zoltan ^{[1
]}

Gyorgy, Bernadett ^{[1
]}

Aczel, Dora ^{[1
]}

Toth, Laszlo ^{[1
]}

Osvath, Peter ^{[1
]}

Fridvalszky, Marcell ^{[1
]}

Teglas, Timea ^{[1
]}

Posa, Aniko ^{[5
]}

Kujach, Sylwester ^{[6
]}

Olek, Robert ^{[7
]}

Kawamura, Takuji ^{[8
]}

Seki, Yasuhiro ^{[8
]}

Suzuki, Katsuhiko ^{[8
]}

Tanisawa, Kumpei ^{[8
]}

Goto, Sataro ^{[1
]}

Kerepesi, Csaba ^{[9
]}

Boldogh, Istvan ^{[10
]}

Ba, Xueqing ^{[11
]}

Davies, Kelvin J. A. ^{[12
,13
,14
]}

Horvath, Steve ^{[15
,16
]}

Radak, Zsolt ^{[1
,8
]}

机构：

[1] Hungarian Univ Sport Sci, Res Inst Sport Sci, Budapest, Hungary

[2] Univ Tsukuba, Fac Hlth & Sport Sci, Sports Neurosci Div, Adv Res Initiat Human High Performance ARIHHP, Tsukuba, Ibaraki 3058574, Japan

[3] Univ Tsukuba, Fac Hlth & Sport Sci, Lab Exercise Biochem & Neuroendocrinol, Tsukuba, Ibaraki 3058574, Japan

[4] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA

[5] Univ Szeged, Fac Sci & Informat, Interdisciplinary Excellence Ctr, Dept Physiol Anat & Neurosc, H-6700 Szeged, Hungary

[6] Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Dept Physiol, Gdansk, Poland

[7] Poznan Univ Phys Educ, Dept Athlet Strength & Conditioning, Poznan, Poland

[8] Waseda Univ, Fac Sport Sci, Tokorozawa 2-579-15, Tokyo, Japan

[9] Eotvos Lorand Res Network, Inst Comp Sci & Control SZTAK, Budapest, Hungary

[10] Univ Texas Med Branch Galveston, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[11] Northeast Normal Univ, Key Lab Mol Epigenet, Minist Educ, Changchun, Jilin, Peoples R China

[12] Univ Southern Calif, Ethel Percy Andrus Gerontol Ctr, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA

[13] Univ Southern Calif, Dornsife Coll Letters Arts & Sci, Dept Biol Sci, Div Mol & Computat Biol, Los Angeles, CA 90089 USA

[14] Univ Southern Calif, USC Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90089 USA

[15] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[16] Cambridge Inst Sci, Altos Labs, Cambridge, England

来源：

GEROSCIENCE | 2023年 / 45卷 / 05期

基金：

美国国家卫生研究院;

关键词：

DNA methylation; DNAmFitAge; Regular exercise; Slower aging; Systemic adaptation;

D O I：

10.1007/s11357-023-00826-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33-88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO(2)max (rho = 0.2, p = 6.4E - 4, r = 0.19, p = 1.2E - 3), Jumpmax (p = 0.11, p = 5.5E - 2, r = 0.13, p = 2.8E - 2), Gripmax (rho = 0.17, p = 3.5E - 3, r = 0.16, p = 5.6E - 3), and HDL levels (rho = 0.18, p = 1.95E - 3, r = 0.19, p = 1.1E - 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration (rho: - 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.

引用

页码：2805 / 2817

页数：13

共 22 条

[1]

Belsky DW, 2022, ELIFE, V11, DOI [10.7554/eLife.73420, 10.7554/eLife.73420.sa0, 10.7554/eLife.73420.sa1, 10.7554/eLife.73420.sa2]

[2] V ROLE OF INACTIVITY IN CHRONIC DISEASES: EVOLUTIONARY INSIGHT AND PATHOPHYSIOLOGICAL MECHANISMS [J].

Booth, Frank W. ;

Roberts, Christian K. ;

Thyfault, John P. ;

Ruegsegger, Gregory N. ;

Toedebusch, Ryan G. .

PHYSIOLOGICAL REVIEWS, 2017, 97 (04) :1351-1402

[3] A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J].

Bostroem, Pontus ;

Wu, Jun ;

Jedrychowski, Mark P. ;

Korde, Anisha ;

Ye, Li ;

Lo, James C. ;

Rasbach, Kyle A. ;

Bostroem, Elisabeth Almer ;

Choi, Jang Hyun ;

Long, Jonathan Z. ;

Kajimura, Shingo ;

Zingaretti, Maria Cristina ;

Vind, Birgitte F. ;

Tu, Hua ;

Cinti, Saverio ;

Hojlund, Kurt ;

Gygi, Steven P. ;

Spiegelman, Bruce M. .

NATURE, 2012, 481 (7382) :463-U72

[4] Advances in high-density lipoprotein physiology: surprises, overturns, and promises [J].

Constantinou, Caterina ;

Karavia, Eleni A. ;

Xepapadaki, Eva ;

Petropoulou, Peristera-Ioanna ;

Papakosta, Eugenia ;

Karavyraki, Marilena ;

Zvintzou, Evangelia ;

Theodoropoulos, Vassilis ;

Filou, Serafoula ;

Hatziri, Aikaterini ;

Kalogeropoulou, Christina ;

Panayiotakopoulos, George ;

Kypreos, Kyriakos E. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2016, 310 (01) :E1-E14

[5] High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus [J].

Drew, Brian G. ;

Duffy, Stephen J. ;

Formosa, Melissa F. ;

Natoli, Alaina K. ;

Henstridge, Darren C. ;

Penfold, Sally A. ;

Thomas, Walter G. ;

Mukhamedova, Nigora ;

de Courten, Barbora ;

Forbes, Josephine M. ;

Yap, Felicia Y. ;

Kaye, David M. ;

van Hall, Gerrit ;

Febbraio, Mark A. ;

Kemp, Bruce E. ;

Sviridov, Dmitri ;

Steinberg, Gregory R. ;

Kingwell, Bronwyn A. .

CIRCULATION, 2009, 119 (15) :2103-U134

[6] Epigenetic differences arise during the lifetime of monozygotic twins [J].

Fraga, MF ;

Ballestar, E ;

Paz, MF ;

Ropero, S ;

Setien, F ;

Ballestart, ML ;

Heine-Suñer, D ;

Cigudosa, JC ;

Urioste, M ;

Benitez, J ;

Boix-Chornet, M ;

Sanchez-Aguilera, A ;

Ling, C ;

Carlsson, E ;

Poulsen, P ;

Vaag, A ;

Stephan, Z ;

Spector, TD ;

Wu, YZ ;

Plass, C ;

Esteller, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10604-10609

[7] Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates [J].

Hannum, Gregory ;

Guinney, Justin ;

Zhao, Ling ;

Zhang, Li ;

Hughes, Guy ;

Sadda, SriniVas ;

Klotzle, Brandy ;

Bibikova, Marina ;

Fan, Jian-Bing ;

Gao, Yuan ;

Deconde, Rob ;

Chen, Menzies ;

Rajapakse, Indika ;

Friend, Stephen ;

Ideker, Trey ;

Zhang, Kang .

MOLECULAR CELL, 2013, 49 (02) :359-367

[8] DNA methylation-based biomarkers and the epigenetic clock theory of ageing [J].

Horvath, Steve ;

Raj, Kenneth .

NATURE REVIEWS GENETICS, 2018, 19 (06) :371-384

[9] DNA methylation age of human tissues and cell types [J].

Horvath, Steve .

GENOME BIOLOGY, 2013, 14 (10)

[10] Reference Standards for Cardiorespiratory Fitness Measured With Cardiopulmonary Exercise Testing: Data From the Fitness Registry and the Importance of Exercise National Database [J].

Kaminsky, Leonard A. ;

Arena, Ross ;

Myers, Jonathan .

MAYO CLINIC PROCEEDINGS, 2015, 90 (11) :1515-1523

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