Plaque attack: Microglia have hard feelings toward amyloid-β

被引：1
|
作者：
Davis, Harvey [1 ]
Attwell, David [1 ]
机构：
[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
来源：
NEURON | 2023年 / 111卷 / 01期
关键词：
D O I：
10.1016/j.neuron.2022.11.014
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Classically, microglia recognize and internalize amyloid-beta (A beta) via it binding to cell surface receptors. In this issue of Neuron, Hu et al.(1) report that microglia "feel"and internalize A beta plaques using the stiffness-sensing channel Piezo1. This could allow new approaches to treating Alzheimer's disease.
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页数：2
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