The role of FOXP3 in non-small cell lung cancer and its therapeutic potentials

被引：11
|
作者：
Peng, Jia [1 ]
Yang, Shucai [3 ]
Ng, Calvin S. H. [1 ]
Chen, George G. [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Hong Kong, Peoples R China
[3] Pingshan Dist Peoples Hosp Shenzhen, Shenzhen, Peoples R China
来源：
PHARMACOLOGY & THERAPEUTICS | 2023年 / 241卷
关键词：
NSCLC; FOXP3; Oncogene; Therapeutic target; REGULATORY T-CELL; TRANSCRIPTION FACTOR FOXP3; ANTITUMOR IMMUNITY; SYSTEMIC THERAPY; BRAIN METASTASES; SUPPRESSOR GENE; BREAST-CANCER; TUMOR-CELLS; EXPRESSION; CISPLATIN;
D O I：
10.1016/j.pharmthera.2022.108333
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although in the last few decades we have witnessed the rapid development of treatments for non-small cell lung cancer (NSCLC), it still remains the leading cause of cancer-related death. Increasing efforts have been devoted to exploring potential biomarkers and molecular targets for NSCLC. Foxp3, a transcription factor that was discovered as a master regulator of regulatory T cells (Tregs), has been found to express abnormally in tumoral cells including lung cancer cells. In recent years, increasing evidence have surfaced, revealing the carcinogenic effect of FOXP3 in lung cancer. In this review, we analyzed and summarized the function of FOXP3, its regulation and therapeutic potentials in NSCLC, with a hope to facilitate the development of novel treatments for NSCLC. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Foxp3 expression in patients with non-small cell lung cancer
    Kalofonos, H.
    Dimitrakopoulos, F. D.
    Papadaki, H.
    Antonacopoulou, A. G.
    Kottorou, A. E.
    Scopa, C. D.
    Gotsis, A.
    Mouzaki, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [2] Association of FOXP3 Expression with Non-small Cell Lung Cancer
    Dimitrakopoulos, Fotinos-Ioannis D.
    Papadaki, Helen
    Antonacopoulou, Anna G.
    Kottorou, Anastasia
    Gotsis, Andreas D.
    Scopa, Chrisoula
    Kalofonos, Haralabos P.
    Mouzaki, Athanasia
    ANTICANCER RESEARCH, 2011, 31 (05) : 1677 - 1683
  • [3] Foxp3 expression and prognosis in early stage non-small cell lung cancer
    Tao, Hiroyuki
    CANCER RESEARCH, 2010, 70
  • [4] The regulation of FOXP3 expression by GLI-1 in non-small cell lung cancer cells and its influence on lung cancer cell stemness
    Qi, H.
    Jia, H.
    Chen, G. G.
    JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (04) : S4 - S4
  • [5] Expression of FOXP3 in the microenvironment of non-small cell lung cancer tissue on the background of the application of immunotherapy
    Romaniuk, A.
    Moskalenko, Y.
    Baryshok, A.
    Moskalenko, R.
    VIRCHOWS ARCHIV, 2024, 485 : S450 - S450
  • [6] FoxP3 genetic variants and risk of non-small cell lung cancer in the Chinese Han population
    He, Yan-Qi
    Bo, Qiao
    Yong, Wei
    Qiu, Zhi-Xin
    Li, Ya-Lun
    Li, Wei-Min
    GENE, 2013, 531 (02) : 422 - 425
  • [7] Foxp3 Genetic Variants And Risk Of Non-Small Cell Lung Cancer In Chinese Han Population
    He, Y.
    Li, W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [8] Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer
    Le, Mai Thi
    Nguyen, Huyen-Thu
    Nguyen, Xuan-Hung
    Do, Xuan-Hai
    Mai, Binh Thanh
    Nguyen, Ha Thi Ngoc
    Than, Uyen Thi Trang
    Nguyen, Thanh-Hong
    HELIYON, 2023, 9 (11)
  • [9] FOXP3D3, the major isoform of FOXP3, promotes proliferation, migration, and invasion in non-small cell lung cancer
    Jia, H.
    Qi, H.
    Peng, J.
    Li, M.
    Chen, G. G.
    ANNALS OF ONCOLOGY, 2019, 30
  • [10] Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3
    Pu, Jiang-Tao
    Zhang, Tao
    He, Kai-Ming
    Zhang, Deng-Guo
    Teng, Zhang-Yu
    Wu, Yun-Fei
    ACTA BIOCHIMICA POLONICA, 2022, 69 (01) : 51 - 57
12345