The role of FOXP3 in non-small cell lung cancer and its therapeutic potentials

被引：11
作者：
Peng, Jia [1 ]
Yang, Shucai [3 ]
Ng, Calvin S. H. [1 ]
Chen, George G. [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Hong Kong, Peoples R China
[3] Pingshan Dist Peoples Hosp Shenzhen, Shenzhen, Peoples R China
来源：
PHARMACOLOGY & THERAPEUTICS | 2023年 / 241卷
关键词：
NSCLC; FOXP3; Oncogene; Therapeutic target; REGULATORY T-CELL; TRANSCRIPTION FACTOR FOXP3; ANTITUMOR IMMUNITY; SYSTEMIC THERAPY; BRAIN METASTASES; SUPPRESSOR GENE; BREAST-CANCER; TUMOR-CELLS; EXPRESSION; CISPLATIN;
D O I：
10.1016/j.pharmthera.2022.108333
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although in the last few decades we have witnessed the rapid development of treatments for non-small cell lung cancer (NSCLC), it still remains the leading cause of cancer-related death. Increasing efforts have been devoted to exploring potential biomarkers and molecular targets for NSCLC. Foxp3, a transcription factor that was discovered as a master regulator of regulatory T cells (Tregs), has been found to express abnormally in tumoral cells including lung cancer cells. In recent years, increasing evidence have surfaced, revealing the carcinogenic effect of FOXP3 in lung cancer. In this review, we analyzed and summarized the function of FOXP3, its regulation and therapeutic potentials in NSCLC, with a hope to facilitate the development of novel treatments for NSCLC. (c) 2022 Elsevier Inc. All rights reserved.
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页数：8
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