Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis

被引：15

作者：

Li, Han ^{[1
,2
]}

Ye, Xiao-feng ^{[1
]}

Su, Yang-shuai ^{[3
]}

He, Wei ^{[3
]}

Zhang, Jian-bin ^{[2
,4
]}

Zhang, Qi ^{[1
]}

Zhan, Li-bin ^{[2
,5
]}

Jing, Xiang-hong ^{[3
]}

机构：

[1] Nanjing Univ Chinese Med, Changzhou Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, Changzhou 213002, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China

[3] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Res Ctr Meridians, Beijing 100700, Peoples R China

[4] Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Acupuncture & Moxibust, Nanjing 211005, Peoples R China

[5] Liaoning Univ Chinese Med, Shenyang 116600, Peoples R China

来源：

CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2023年 / 29卷 / 09期

基金：

中国国家自然科学基金;

关键词：

acupuncture and moxibustion; ulcerative colitis; mucosal healing; intestinal epithelial cells regeneration and death; tight junction function; gut microbiota; TIGHT JUNCTION PERMEABILITY; MESENCHYMAL STEM-CELLS; NECROSIS-FACTOR-ALPHA; GUT MICROBIOTA; INFLAMMATORY RESPONSES; EPITHELIAL-CELLS; BARRIER; RAT; PATHOGENESIS; AUTOPHAGY;

D O I：

10.1007/s11655-022-3531-x

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall (mechanical barrier) injury with the imbalance between intestinal epithelial cells (IECs) regeneration and death, as well as tight junction (TJ) dysfunction. It is suggested that biological barrier (gut microbiota), chemical barrier (mucus protein layer, MUC) and immune barrier (immune cells) all take part in the imbalance, leading to mechanical barrier injury. Lots of experimental studies reported that acupuncture and moxibustion on UC recovery by adjusting the gut microbiota, MUC and immune cells on multiple targets and pathways, which contributes to the balance of IEC regeneration and death, as well as TJ structure recovery in animals. Moreover, the validity and superiority of acupuncture and moxibustion were also demonstrated in clinic. This study aims to review the achievements of acupuncture and moxibustion on mucosal healing and analyse the underlying mechanisms.

引用

页码：847 / 856

页数：10

共 104 条

[1] Outer Membrane Vesicles and Soluble Factors Released by Probiotic Escherichia coil Nissle 1917 and Commensal ECOR63 Enhance Barrier Function by Regulating Expression of Tight Junction Proteins in Intestinal Epithelial Cells [J].