What's new about the tumor microenvironment of urothelial carcinoma?

被引：1

作者：

Coelho, Joao Queiros ^{[1
]}

Ramos, Maria Joao ^{[1
]}

Ranchor, Ridhi ^{[1
]}

Pichel, Rita ^{[1
]}

Guerra, Laura ^{[1
]}

Miranda, Hugo ^{[1
]}

Simoes, Joana ^{[1
]}

Azevedo, Sergio Xavier ^{[1
]}

Febra, Joana ^{[1
]}

Araujo, Antonio ^{[1
,2
]}

机构：

[1] Unidade Local Saude Santo Antonio, Porto, Portugal

[2] Univ Porto, ICBAS Sch Med & Biomed Sci, Oncol Res Unit, UMIB Unit Multidisciplinary Res Biomed, Porto, Portugal

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2024年 / 26卷 / 07期

关键词：

Tumor microenvironment; Urothelial cancer; Bladder cancer; Immunomodulation; Immunotherapy; CISPLATIN-INELIGIBLE PATIENTS; MATRIX METALLOPROTEINASES; SUPPRESSOR-CELLS; URINARY-BLADDER; SINGLE-ARM; PEMBROLIZUMAB; MULTICENTER; MACROPHAGES; EXPRESSION; PROGNOSIS;

D O I：

10.1007/s12094-024-03384-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Urothelial carcinoma is a significant global health concern that accounts for a substantial part of cancer diagnoses and deaths worldwide. The tumor microenvironment is a complex ecosystem composed of stromal cells, soluble factors, and altered extracellular matrix, that mutually interact in a highly immunomodulated environment, with a prominent role in tumor development, progression, and treatment resistance. This article reviews the current state of knowledge of the different cell populations that compose the tumor microenvironment of urothelial carcinoma, its main functions, and distinct interactions with other cellular and non-cellular components, molecular alterations and aberrant signaling pathways already identified. It also focuses on the clinical implications of these findings, and its potential to translate into improved quality of life and overall survival. Determining new targets or defining prognostic signatures for urothelial carcinoma is an ongoing challenge that could be accelerated through a deeper understanding of the tumor microenvironment.

引用

页码：1549 / 1560

页数：12

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