Preoperative Mechanical Bowel Preparation for Gynecologic Surgeries: A Systematic Review with Meta-analysis

Objective: To assess the efficacy and safety of mechanical bowel preparation (MBP) before benign laparoscopic or vaginal gynecologic surgeries. Data Sources: Database searches of MEDLINE (PubMed), Embase (OVID), Cochrane Central Register of Controlled Tri-als, and Web of Sciences and citations and reference lists published up to December 2021. Methods of Study Selection: Randomized clinical trials in any language comparing MBP with no preparation were included. Two reviewers independently screened 925 records and extracted data from 12 selected articles and assessed the risk of bias with the Cochrane risk-of-bias tool for randomized trials tool. A random-effects model was used for the analysis. Surgeon findings (surgical field view, quality of bowel handling and bowel preparation), operative outcomes (blood loss, operative time, length of stay, surgical site infection), and patient's preoperative symptoms and satisfaction were collected. Tabulation, Integration, and Results: Thirteen studies (1715 patients) assessing oral and rectal preparations before laparo-scopic and vaginal gynecologic surgeries were included. No significant differences were observed with or without MBP on surgical field view (primary outcome, risk ratio [RR] 1.01, 95% confidence interval [CI] 0.97-1.05, p = .66, I2 = 0%), bowel handling (RR 1.01, 95% CI 0.95-1.08, p = .78, I2 = 67%), or bowel preparation. In addition, there were no statistically sig-nificant differences in perioperative findings. MBP was associated with increased pain (mean difference [MD] 11.62[2.80 -20.44], I2 = 76, p = .01), weakness (MD 10.73[0.60-20.87], I2 = 94, p = .04), hunger (MD 17.52 [8.04-27.00], I2 = 83, p = .0003), insomnia (MD 10.13[0.57-19.68], I2 = 82, p = .04), and lower satisfaction (RR 0.68, 95% CI 0.53-0.87, I2 = 76%, p = .002) compared with controls. Conclusions: MBP has not been associated with improved surgical field view, bowel handling, or operative outcome. How-ever, in view of the adverse effects induced, its routine use before benign gynecologic surgeries should be abandoned. Jour-nal of Minimally Invasive Gynecology (2023) 30, 695-704. & COPY; 2023 AAGL. All rights reserved.