Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity

被引：6

作者：

Monzo, Carolina ^{[1
,2
]}

Gkioni, Lisonia ^{[1
]}

Beyer, Andreas ^{[2
]}

Valenzano, Dario Riccardo ^{[3
,4
]}

Gronke, Sebastian ^{[1
]}

Partridge, Linda ^{[1
,5
]}

机构：

[1] Max Planck Inst Biol Ageing, Dept Biol Mech Ageing, North Rhine Westphalia, D-50931 Cologne, Germany

[2] Univ Cologne, Fac Med, Cologne Excellence Cluster Cellular Stress Respons, D-50931 Cologne, Germany

[3] Max Planck Inst Biol Ageing, Microbiome Host Interact Ageing Grp, North Rhine Westphalia, D-50931 Cologne, Germany

[4] Leibniz Inst Aging, Fritz Lipmann Inst, Evolutionary Biol Microbiome Host Interact Aging G, D-07745 Jena, Thuringia, Germany

[5] UCL, Inst Hlth Ageing, Genet Evolut & Environm Grp, London WC1E 6BT, England

来源：

CELL REPORTS | 2023年 / 42卷 / 07期

基金：

欧洲研究理事会;

关键词：

IMMUNOGLOBULIN-G; ANTIBODY; MICROBIOTA; HEALTH; MICE; HYPERMUTATION; SENESCENCE; HALLMARKS; DISEASES; REVEALS;

D O I：

10.1016/j.celrep.2023.112722

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging impairs the capacity to respond to novel antigens, reducing immune protection against pathogens and vaccine efficacy. Dietary restriction (DR) extends life-and health span in diverse animals. However, little is known about the capacity of DR to combat the decline in immune function. Here, we study the changes in B cell receptor (BCR) repertoire during aging in DR and control mice. By sequencing the variable region of the BCR heavy chain in the spleen, we show that DR preserves diversity and attenuates the increase in clonal expansions throughout aging. Remarkably, mice starting DR in mid-life have repertoire diversity and clonal expansion rates indistinguishable from chronic DR mice. In contrast, in the intestine, these traits are unaffected by either age or DR. Reduced within-individual B cell repertoire diversity and increased clonal expansions are correlated with higher morbidity, suggesting a potential contribution of B cell repertoire dynamics to health during aging.

引用

页数：17

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