Introducing a New Type of Drug Delivery System Based on the Silicon Carbide Monolayer

被引：5

作者：

Kadhim, Mustafa M. ^{[1
]}

Hachim, Safa K. ^{[2
,3
]}

Alomar, S. ^{[1
]}

Taban, Taleeb Zedan ^{[4
]}

Abdullaha, Sallal A. H. ^{[5
]}

Alnasoud, Najla ^{[6
]}

机构：

[1] Al Farahidi Univ, Med Lab Tech Dept, 10022, Baghdad, Baghdad, Iraq

[2] Islamic Univ, Coll Tech Engn, Baghdad, Najaf, Iraq

[3] Al Turath Univ Coll, Med Lab Tech Dept, Baghdad, Baghdad, Iraq

[4] Kut Univ Coll, Laser & Optoelect Engn Dept, 52001, Kut Wasit, Baghdad, Iraq

[5] Dijlah Univ Coll, 10022, Baghdad, Baghdad, Iraq

[6] Univ Mashreq, Coll Pharm, 10021, Baghdad, Iraq

来源：

SILICON | 2023年 / 15卷 / 10期

关键词：

Silicon carbide; Nanobiotechnology; Chlormethine; Drug delivery; ADSORPTION BEHAVIOR; NANOTECHNOLOGY; CARBON; SUPERCONDUCTIVITY; NANOCARRIERS; NANOSCIENCE; FULLERENES; DISCOVERY; ENERGIES; MEDICINE;

D O I：

10.1007/s12633-023-02346-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Two-dimensional inorganic nanomaterials are commonly used in nanobiotechnology in order to improve horizontal inorganic systems for medicinal purposes. In this research, a silicon carbide (SiC) monolayer with a chlormethine (CM) anticancer drug is investigated by performing density functional theory (DFT) calculations. The interaction between host and guest complexes with different configurations, charge transfer (CT), interaction strength, and structural geometries are also presented. Using the SiC monolayer with CM is found to be more efficient for biofunctionalization with the interaction energy (E-int) of - 29.05 kcal/mol. The charge transfer from the adsorbed CM to SiC was confirmed by the Hirshfeld surface analysis. The results can provide insights into the application of nano-biomaterials in the fields of biology, nanomedicine and drug delivery.

引用

页码：4317 / 4323

页数：7

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