Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent of packing. To enhance the range of properties, granular composites can be formed with a hydrogel interstitial matrix between the packed microgels, allowing for material flow and then stabilization after crosslinking. This approach allows for distinct compartments (i.e., microgels and interstitial space) with varied properties to engineer complex material behaviors. However, a thorough investigation of how the compositions and ratios of microgels and interstitial matrices influence material properties has not been performed. Herein, granular hydrogel composites are fabricated by combining fragmented hyaluronic acid (HA) microgels with interstitial matrices consisting of photocrosslinkable HA. Microgels of varying compressive moduli (10-70 kPa) are combined with interstitial matrices (0-30 vol.%) with compressive moduli varying from 2-120 kPa. Granular composite structure (confocal imaging), mechanics (local and bulk), flow behavior (rheology), and printability are thoroughly assessed. Lastly, variations in the interstitial matrix chemistry (covalent vs guest-host) and microgel degradability are investigated. Overall, this study describes the influence of granular composite composition on structure and mechanical properties of granular hydrogels towards informed designs for future applications.
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Correa, Santiago
;
Grosskopf, Abigail K.
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Stanford Univ, Chem Engn, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Grosskopf, Abigail K.
;
Hernandez, Hector Lopez
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机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Hernandez, Hector Lopez
;
Chan, Doreen
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机构:
Stanford Univ, Chem, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Chan, Doreen
;
Yu, Anthony C.
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h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Yu, Anthony C.
;
Stapleton, Lyndsay M.
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h-index: 0
机构:
Stanford Univ, Bioengn, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Stapleton, Lyndsay M.
;
Appel, Eric A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Bioengn, ChEM H Inst, Stanford, CA 94305 USA
Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA
Stanford Univ, Pediat Endocrinol, Sch Med, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Daly, Andrew C.
;
Prendergast, Margaret E.
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h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Prendergast, Margaret E.
;
Hughes, Alex J.
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h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Hughes, Alex J.
;
Burdick, Jason A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Daly, Andrew C.
;
Riley, Lindsay
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h-index: 0
机构:
Duke Univ, Dept Biomed Engn, Durham, NC 27706 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Riley, Lindsay
;
Segura, Tatiana
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h-index: 0
机构:
Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
Duke Univ, Dept Dermatol, Durham, NC 27708 USA
Duke Univ, Dept Neurol, Durham, NC 27708 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Segura, Tatiana
;
Burdick, Jason A.
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h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Darling, Nicole J.
;
Xi, Weixian
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Orthoped Surg, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Xi, Weixian
;
Sideris, Elias
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机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Sideris, Elias
;
Anderson, Alexa R.
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机构:
Duke Univ, Dept Biomed Engn, 101 Sci Dr Campus Box 90281, Durham, NC 27708 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Anderson, Alexa R.
;
Pong, Cassie
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Pong, Cassie
;
Carmichael, S. Thomas
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, 621 Charles Young Dr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Carmichael, S. Thomas
;
Segura, Tatiana
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Biomed Engn, 101 Sci Dr Campus Box 90281, Durham, NC 27708 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Correa, Santiago
;
Grosskopf, Abigail K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Chem Engn, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Grosskopf, Abigail K.
;
Hernandez, Hector Lopez
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Hernandez, Hector Lopez
;
Chan, Doreen
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Chem, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Chan, Doreen
;
Yu, Anthony C.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Yu, Anthony C.
;
Stapleton, Lyndsay M.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Bioengn, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
Stapleton, Lyndsay M.
;
Appel, Eric A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Bioengn, ChEM H Inst, Stanford, CA 94305 USA
Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA
Stanford Univ, Pediat Endocrinol, Sch Med, Stanford, CA 94305 USAStanford Univ, Mat Sci & Engn, Stanford, CA USA
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Daly, Andrew C.
;
Prendergast, Margaret E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Prendergast, Margaret E.
;
Hughes, Alex J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Hughes, Alex J.
;
Burdick, Jason A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Daly, Andrew C.
;
Riley, Lindsay
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Biomed Engn, Durham, NC 27706 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Riley, Lindsay
;
Segura, Tatiana
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
Duke Univ, Dept Dermatol, Durham, NC 27708 USA
Duke Univ, Dept Neurol, Durham, NC 27708 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
Segura, Tatiana
;
Burdick, Jason A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Bioengn, Philadelphia, PA 19104 USA
机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Darling, Nicole J.
;
Xi, Weixian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Orthoped Surg, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Xi, Weixian
;
Sideris, Elias
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Sideris, Elias
;
Anderson, Alexa R.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Biomed Engn, 101 Sci Dr Campus Box 90281, Durham, NC 27708 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Anderson, Alexa R.
;
Pong, Cassie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Pong, Cassie
;
Carmichael, S. Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, 621 Charles Young Dr, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA
Carmichael, S. Thomas
;
Segura, Tatiana
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Biomed Engn, 101 Sci Dr Campus Box 90281, Durham, NC 27708 USAUniv Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA