Epidemiological and genetic characteristics of respiratory syncytial virus infection in children from Hangzhou after the peak of COVID-19

被引：9
作者：
Guo, Ya-jun [1 ]
Wang, Bing-han [2 ]
Li, Lin [1 ]
Li, Ya-ling [3 ]
Chu, Xiao-li [1 ]
Li, Wei [1 ,4 ]
机构：
[1] Zhejiang Univ, Childrens Hosp,Sch Med, Natl Clin Res Ctr Child Hlth, Dept Clin Lab, Hangzhou 310052, Peoples R China
[2] Zhejiang Univ, Sch Med, Sch Publ Hlth, Hangzhou 310052, Peoples R China
[3] Zhejiang LAB, Hangzhou 310052, Peoples R China
[4] Zhejiang Univ, Childrens Hosp, Sch Med, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China
来源：
JOURNAL OF CLINICAL VIROLOGY | 2023年 / 158卷
关键词：
Respiratory syncytial virus; COVID-19; Children; Genotype; GROUP-A; CIRCULATION PATTERNS; CLINICAL SEVERITY; G-PROTEIN; GENOTYPE; ON1;
D O I：
10.1016/j.jcv.2022.105354
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Background: Respiratory syncytial virus (RSV) is one of the main pathogens that causes acute lower respiratory tract infection (ARTI) in infants. During the Coronavirus Disease 2019 (COVID-19) pandemic, although strict interventions have been implemented, RSV infection has not decreased. Objectives: To study the epidemiological and genetic characteristics of RSV circulating in Hangzhou after the peak of COVID-19. Methods: A total of 1225 nasopharyngeal swabs were collected from outpatients with ARTIs from July 2021 to January 2022 in The Children's Hospital, Zhejiang University School of Medicine. Results: A total of 267 (21.79%) of the 1225 samples were RSV positive. There was no gender bias. However, an obvious age preference for infection was observed, and children aged 3-6 years were more susceptible, which was very different from previous RSV pandemic seasons. Phylogenetic analysis of 115 sequenced RSV isolates showed that all the RSV-A viruses belong to the ON1 subtype, which could be clustered into three clusters. While all the RSV-B viruses belong to BA9. Further analysis of the mutations highlights the fixation of ten mutations, which should be given extra attention regarding their biological properties. Conclusion: The incidence of RSV infection in preschool children reported in this study is high. Phylogenetic analysis showed that the subtype A ON1 genotype was the dominant strain in Hangzhou from July 2021 to January 2022.
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