Level of maternal antibodies against respiratory syncytial virus (RSV) nucleoprotein at birth and risk of RSV very severe lower respiratory tract infection

被引：5

作者：

Receveur, Matthieu ^{[1
,2
,3
]}

Ottmann, Michele ^{[4
]}

Reynes, Jean-Marc ^{[4
,5
]}

Eleouet, Jean-Francois ^{[6
]}

Galloux, Marie ^{[6
]}

Receveur, Aurore ^{[7
,8
]}

Ploin, Dominique ^{[1
,4
]}

Fiorini, Sylvie ^{[4
]}

Rivat, Nathalie ^{[4
]}

Valette, Martine ^{[2
,9
]}

Lina, Bruno ^{[2
,3
,4
,9
]}

Casalegno, Jean-Sebastien ^{[2
,3
,4
,9
]}

机构：

[1] Hosp Civils Lyon, Hop Femme Mere Enfant, Serv Reanimat Pediat & Accueil Urgences, 59 Blvd Pinel, F-69500 Bron, France

[2] Hosp Civils Lyon, Hop Croix Rousse, Inst Agents Infect, Lyon, France

[3] Univ Claude Bernard Lyon 1, Univ Lyon, Fac Med Lyon Est, Lyon, France

[4] Univ Claude Bernard Lyon 1, Univ Lyon,Lab Virol & Pathol Humaines Virpath, Ecole Normale Super Lyon, Inserm,U1111,CNRS,UMR5308,Ctr Int Rech Infectiol, Lyon, France

[5] Univ Paris Cite, Inst Pasteur, Unite Environm & Risques Infect, Paris, France

[6] Univ Paris Saclay, INRAE, Unite Virol & Immunol Mol, Jouy En Josas, France

[7] SPC, Pacific Community, OFP FEMA, Noumea, New Caledonia

[8] Univ Nouvelle Caledonie, Univ Reunion, IFREMER, IRD,CNRS,UMR9220,ENTROPIE, Noumea, New Caledonia

[9] Hosp Civils Lyon, Hop Croix Rousse, Inst Agents Infect IAI, Lab Virol,Ctr Natl Reference Virus Infect Resp, Lyon, France

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2023年 / 17卷 / 01期

关键词：

infants; lower respiratory tract infection (LRTI); maternal antibodies; nucleoprotein; respiratory syncytial virus; vaccine; YOUNG-CHILDREN; NEUTRALIZING ANTIBODIES; VACCINE DEVELOPMENT; UNITED-STATES; INFANTS; DISEASE; HOSPITALIZATIONS; PROTECTION; BURDEN;

D O I：

10.1111/irv.13025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background The nucleoprotein (N protein) of respiratory syncytial virus (RSV) is a candidate antigen for new RSV vaccine development. The aim of the present study was to investigate the association between maternal antibody titers against the RSV N protein at birth and the newborns' risk of developing very severe lower respiratory tract infection (VS-LRTI). Methods In this single-center prospective cohort study, 578 infants born during the RSV epidemic season in France were included. Among these, 36 were hospitalized for RSV VS-LRTI. A generalized linear model was used to test the occurrence of a VS-LRTI in function of sex, mode of delivery, parity of the mother, type of pregnancy, date of birth in relation to the peak of the epidemic, and antibody titer against N protein. Results All cord blood samples had detectable antibodies against N protein. The mean titers were significantly lower in newborns with risk factors for RSV severe LRTI (preterm infants, birth before the peak epidemic, multiparous mother). There was no association between antibody titer against the N protein and a protection against VS-LRTI. Conclusions Further studies are needed to support the hypothesis that transfer of maternal antibodies against the RSV N protein can provide a significant immune protection early in infancy and that N protein candidate vaccine may be a suitable target for maternal vaccine.

引用

页数：8

共 32 条

[1] Safety and immunogenicity evaluation of recombinant BCG vaccine against respiratory syncytial virus in a randomized, double-blind, placebo-controlled phase I clinical trial [J].