Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour

被引：6

作者：

Gurrado, Angela ^{[1
]}

Pasculli, Alessandro ^{[1
]}

Avenia, Nicola ^{[2
]}

Bellantone, Rocco ^{[3
]}

Boniardi, Marco ^{[4
]}

Boschin, Isabella Merante ^{[5
]}

Calo, Pietro Giorgio ^{[6
]}

Camandona, Michele ^{[7
]}

Cavallaro, Giuseppe ^{[8
]}

Cianchi, Fabio ^{[9
]}

Conzo, Giovanni ^{[10
]}

D'Andrea, Vito ^{[11
]}

De Crea, Carmela ^{[12
,13
]}

De Pasquale, Loredana ^{[14
]}

Del Rio, Paolo ^{[15
]}

Di Meo, Giovanna ^{[1
]}

Dionigi, Gianlorenzo ^{[16
,17
]}

Dobrinja, Chiara ^{[18
]}

Docimo, Giovanni ^{[19
]}

Fama, Fausto ^{[20
]}

Galimberti, Attilio ^{[21
]}

Giacomelli, Laura ^{[22
]}

Graceffa, Giuseppa ^{[23
]}

Iacobone, Maurizio ^{[5
]}

Innaro, Nadia ^{[24
]}

Lombardi, Celestino Pio ^{[3
]}

Materazzi, Gabriele ^{[25
]}

Medas, Fabio ^{[6
]}

Mullineris, Barbara ^{[26
]}

Oragano, Luigi ^{[27
]}

Palestini, Nicola ^{[28
]}

Perigli, Giuliano ^{[9
]}

Pezzolla, Angela ^{[1
]}

Prete, Francesco Paolo ^{[1
]}

Raffaelli, Marco ^{[12
,13
]}

Renzulli, Giuseppina ^{[29
]}

Rosato, Lodovico ^{[30
]}

Scerrino, Gregorio ^{[23
]}

Sgaramella, Lucia Ilaria ^{[1
]}

Sorrenti, Salvatore ^{[31
]}

Testini, Carlotta ^{[9
]}

Veroux, Massimiliano ^{[32
]}

Gasparri, Guido ^{[7
]}

Testini, Mario ^{[1
]}

机构：

[1] Univ Med Sch Bari, Dept Precis & Regenerat Med & Ionian Area DiMePre, I-70124 Bari, Italy

[2] Univ Perugia, S Maria Univ Hosp, Gen & Endocrine Surg Unit, I-05100 Terni, Italy

[3] Fdn Policlin Univ Agostino Gemelli IRCCS, Div Endocrine & Metab Surg, I-00168 Rome, Italy

[4] ASST Grande Osped Metropolitano Niguarda, Gen Oncol & Mini Invas Surg Dept, I-20162 Milan, Italy

[5] Univ Padua, Dept Surg Oncol & Gastroenterol, Endocrine Surg Unit, Padua I-35143, Italy

[6] Univ Cagliari, Dept Surg Sci, I-09124 Cagliari, Italy

[7] Univ Turin, Molinette Hosp, Dept Surg Sci, I-10126 Turin, Italy

[8] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-00185 Rome, Italy

[9] Univ Florence, Dept Expt & Clin Med, Digest Surg Unit, I-50134 Florence, Italy

[10] Univ Campania Luigi Vanvitelli, Dept Med & Traslat Sci, Div Gen Oncol Mini Invas & Obes Surg, I-80138 Naples, Italy

[11] Sapienza Univ, Dept Surg Sci, I-00185 Rome, Italy

[12] Fdn Policlin Univ Agostino Gemelli IRCCS, UOC Chirurg Endocrina & Metab, I-00168 Rome, Italy

[13] Univ Cattolica Sacro Cuore, Ctr Ric Chirurg Ghiandole Endocrine & Obes, I-00168 Rome, Italy

[14] San Paolo Hosp, Head & Neck Dept, I-20142 Milan, Italy

[15] Univ Parma, Parma Univ Hosp, Dept Gen & Specialist Surg, I-43126 Parma, Italy

[16] Ist Auxol Italiano IRCCS, Div Surg, I-20122 Milan, Italy

[17] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy

[18] Univ Trieste, Dept Med Surg & Hlth Sci, I-34125 Trieste, Italy

[19] Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy

[20] Univ Hosp G Martino, Dept Human Pathol Adulthood & Childhood G Barresi, I-98125 Messina, Italy

[21] Legnano Gen Hosp, Dept Surg, I-20025 Legnano, Italy

[22] Sapienza Univ, Dept Gen & Special Surg, I-00185 Rome, Italy

[23] Univ Palermo, Dept Surg Oncol & Oral Sci, I-90127 Palermo, Italy

[24] Magna Graecia Univ Catanzaro, Unit Endocrine Surg, AOU Dulbecco, I-88100 Catanzaro, Italy

[25] Univ Hosp Pisa, Dept Surg Med & Mol Pathol & Crit Area, Endocrine Surg Unit, I-56121 Pisa, Italy

[26] Modena Hosp, Unit Gen Surg Emergency & New Technol, I-41126 Modena, Italy

[27] San Biagio Hosp, Surg Unit Gen Surg, I-28845 Domodossola, Italy

[28] Fdn Piemontese Oncol, Candiolo Canc Inst, I-10060 Candiolo, Italy

[29] Univ Med Sch Bari, Dept Precis & Regenerat Med & Ionian Area DiMePre, Unit Pathol, I-70124 Bari, Italy

[30] Ivrea Hosp, Dept Surg, ASL TO4, I-10015 Ivrea, Italy

[31] Sapienza Univ, Dept Surg, I-00185 Rome, Italy

[32] Univ Catania, Dept Med & Surg Sci & Adv Technol, I-95100 Catania, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 19期

关键词：

parathyroid carcinoma; atypical thyroid tumour; parathyroidectomy; hyperparathyroidism; 2022 WHO criteria; PRIMARY HYPERPARATHYROIDISM; PREOPERATIVE DIAGNOSIS; FEATURES; HYPERCALCEMIA; ULTRASOUND; GUIDELINES; MANAGEMENT; SURVIVAL; CANCER; LEVEL;

D O I：

10.3390/jcm12196297

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT). Methods: All relevant information was collected about PC and APT patients treated between 2009 and 2021. Results: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 +/- 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates (p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%. Conclusions: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.

引用

页数：15

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