Solvent-Free Synthesis of 1, 4 Dihydropyridines Derivatives via Hantzsch Reaction Employing MgFe2O4 MNPs: An Efficient and Recyclable Heterogeneous Catalyst

Pristine magnesium spinel ferrite nanoparticles (MgFe2O4, MNPs) were fabricated via sol-gel auto combustion and elucidated by XRD, SEM, EDAX, TEM, FTIR, BET and VSM for structural and physical characteristics. Fabricated MgFe2O4 MNPs found to be an efficient, robust and magnetically separable reusable heterogeneous catalyst for one pot three component solvent free synthesis of biologically important 1,4-dihydropyridines (1, 4 DHP's) via Hantzsch condensation reaction. This convention was effectively appropriate to an extensive variety physically distinct aryl-aldehydes with ethyl acetoacetate and ammonium acetate to manage the required 1,4-dihydropyridines (1, 4 DHP's) derivatives. The structural investigations approved the sustainability and reusability of the MgFe2O4, MNPs towards current organic reactions. The novelties of this protocol are operational cleanness, short reaction time, nontoxic, inexpensive and magnetically separable heterogeneous catalyst may perhaps easily be recycled deprived of remarkable decline in catalytic performance.