Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

被引：12

作者：

Miller, Rachel L. ^{[1
]}

Schuh, Holly ^{[3
]}

Chandran, Aruna ^{[3
]}

Aris, Izzuddin M. ^{[4
,5
]}

Bendixsen, Casper ^{[10
]}

Blossom, Jeffrey ^{[11
]}

Breton, Carrie ^{[12
]}

Camargo Jr, Carlos A. ^{[6
,7
]}

Canino, Glorisa ^{[13
]}

Carroll, Kecia N. ^{[1
]}

Commodore, Sarah ^{[14
]}

Cordero, Jose F. ^{[15
]}

Dabelea, Dana M. ^{[16
]}

Ferrara, Assiamira ^{[18
]}

Fry, Rebecca C. ^{[19
]}

Ganiban, Jody M. ^{[20
]}

Gern, James E. ^{[21
]}

Gilliland, Frank D. ^{[12
]}

Gold, Diane R. ^{[8
,9
]}

Habre, Rima ^{[12
]}

Hare, Marion E. ^{[22
]}

Harte, Robyn N. ^{[17
]}

Hartert, Tina ^{[23
]}

Hasegawa, Kohei ^{[7
]}

Hershey, Gurjit K. Khurana ^{[24
,25
]}

Jackson, Daniel J.

Joseph, Christine ^{[26
]}

Kerver, Jean M. ^{[27
]}

Kim, Haejin ^{[26
]}

Litonjua, Augusto A. ^{[28
]}

Marsit, Carmen J. ^{[30
]}

McEvoy, Cindy ^{[31
]}

Mendonca, Eneida A. ^{[24
,25
]}

Moore, Paul E.

Nkoy, Flory L. ^{[32
]}

O'Connor, Thomas G. ^{[29
]}

Oken, Emily ^{[4
,5
]}

Ownby, Dennis ^{[26
]}

Perzanowski, Matthew ^{[2
]}

Rivera-Spoljaric, Katherine ^{[33
]}

Ryan, Patrick H. ^{[24
,25
]}

Singh, Anne Marie

Stanford, Joseph B. ^{[32
]}

Wright, Rosalind J. ^{[1
]}

Wright, Robert O. ^{[1
]}

Zanobetti, Antonella ^{[9
]}

Zoratti, Edward ^{[26
]}

Johnson, Christine C. ^{[26
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY USA

[2] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Harvard Med Sch, Dept Populat Med, Boston, MA USA

[5] Harvard Pilgrim Hlth Care Inc, Boston, MA USA

[6] Harvard Med Sch, Dept Epidemiol, Boston, MA USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA USA

[8] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA

[9] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA

[10] Marshfield Clin Res Inst, Marshfield, WI USA

[11] Harvard Univ, Ctr Geog Anal, Cambridge, MA USA

[12] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[13] Univ Puerto Rico, Behav Sci Res Inst, San Juan, PR USA

[14] Med Univ South Carolina, Charleston, SC USA

[15] Univ Georgia, Coll Publ Hlth, Athens, GA USA

[16] Univ Colorado Anschutz Med Campus, Aurora, CO USA

[17] Colorado Sch Publ Hlth, Aurora, CO USA

[18] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA

[19] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[20] George Washington Univ, Washington, DC USA

[21] Univ Wisconsin, Sch Med & Publ Heath, Madison, WI USA

[22] Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA

[23] Vanderbilt Univ, Sch Med, Nashville, TN USA

[24] Univ Cincinnati, Cincinnati, OH USA

[25] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[26] Henry Ford Hlth, Detroit, MI USA

[27] Michigan State Univ, Coll Human Med, Dept Epidemiol & Biostat, E Lansing, MI USA

[28] Golisano Childrens Hosp, Dept Pediat, Div Pediat Pulm Med, Rochester, NY USA

[29] Univ Rochester, Med Ctr, Sch Med & Dent, Rochester, NY USA

[30] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA

[31] Oregon Hlth & Sci Univ, Portland, OR USA

[32] Univ Utah Hlth, Salt Lake City, UT USA

[33] Washington Univ, St Louis Childrens Hosp, St Louis, MO USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 152卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Asthma; recurrent exacerbations; incidence rates; environmental and social determinants of asthma; UNITED-STATES; RISK-FACTORS; PHENOTYPES; AGE;

D O I：

10.1016/j.jaci.2023.03.016

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2-to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents. (J Allergy Clin Immunol 2023;152:84-93.)

引用

页码：84 / 93

页数：10