Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines

被引：0

作者：

Kim, Hyun Jung ^{[1
,2
,3
]}

Chang, Ha Kyun ^{[4
]}

Lee, Yul Min ^{[1
]}

Heo, Kyun ^{[1
,2
,3
]}

机构：

[1] Kookmin Univ, Dept Biopharmaceut Chem, Seoul 02707, South Korea

[2] Kookmin Univ, Sch Appl Chem, Biopharmaceut Chem Major, Seoul 02707, South Korea

[3] Kookmin Univ, Antibody Res Inst, Seoul 02707, South Korea

[4] Korea Univ, Coll Med, Dept Obstet & Gynecol, Ansan Hosp,Coll Med, Ansan 15355, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

catecholamine; ovarian cancer; invasion; CXCL1; CXCL8; MELANOMA TUMOR-GROWTH; CELL-MIGRATION; STRESS; EXPRESSION; MICROENVIRONMENT; BINDING; ARREST; SYSTEM;

D O I：

10.3390/ijms241814104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and angiogenesis of ovarian cancer. In this study, we analyzed the conditioned media in SKOV3 ovarian cancer cell lines treated with catecholamines to identify secreted proteins responding to chronic stress. Here, we observed that epinephrine and norepinephrine enhanced the secretion and mRNA expression of CXC-chemokines (CXCL1, 2, 3, and 8). Neutralizing antibodies to CXCL8 and CXCL8 receptor (CXCR2) inhibitors significantly reduced catecholamine-mediated invasion of SKOV3 cells. Finally, we found that the concentration of CXCL1 and CXCL8 in the plasma of ovarian cancer patients increased with stage progression. Taken together, these findings suggest that stress-related catecholamines may influence ovarian cancer progression through the secretion of CXC-chemokines.

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页数：13

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