Targeting STAT5B in T-cell acute lymphoblastic leukemia

被引：0

作者：

Veloso, Alexandra ^{[1
,2
]}

Cools, Jan ^{[1
,2
]}

机构：

[1] Katholieke Univ Leuven, Leuven, Belgium

[2] VIB, Leuven, Belgium

来源：

BLOOD | 2023年 / 142卷 / 03期

关键词：

INHIBITION;

D O I：

10.1182/blood.2023020639

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Tremblay et al demonstrate that STAT5B activation drives proliferation, self-renewal, and chemoresistance of leukemia stem cells (LSCs) in an early T-cell precursor acute lymphoblastic leukemia mouse model and explore STAT5B as a direct therapeutic target (see figure).(1)

引用

页码：215 / 217

页数：3

共 11 条

[1] Functional Consequences of Mutations in Myeloproliferative Neoplasms [J].

Constantinescu, Stefan N. ;

Vainchenker, William ;

Levy, Gabriel ;

Papadopoulos, Nicolas .

HEMASPHERE, 2021, 5 (06) :E578

[2] Structural and functional consequences of the STAT5BN642H driver mutation [J].

de Araujo, Elvin D. ;

Erdogan, Fettah ;

Neubauer, Heidi A. ;

Meneksedag-Erol, Deniz ;

Manaswiyoungkul, Pimyupa ;

Eram, Mohammad S. ;

Seo, Hyuk-Soo ;

Qadree, Abdul K. ;

Israelian, Johan ;

Orlova, Anna ;

Suske, Tobias ;

Pham, Ha T. T. ;

Boersma, Auke ;

Tangermann, Simone ;

Kenner, Lukas ;

Ruelicke, Thomas ;

Dong, Aiping ;

Ravichandran, Manimekalai ;

Brown, Peter J. ;

Audette, Gerald F. ;

Rauscher, Sarah ;

Dhe-Paganon, Sirano ;

Moriggl, Richard ;

Gunning, Patrick T. .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] The genetics and molecular biology of T-ALL [J].

Girardi, Tiziana ;

Vicente, Carmen ;

Cools, Jan ;

De Keersmaecker, Kim .

BLOOD, 2017, 129 (09) :1113-1123

[4] A STAT5B-CD9 axis determines self-renewal in and leukemic stem cells [J].

Kollmann, Sebastian ;

Grausenburger, Reinhard ;

Klampfl, Thorsten ;

Prchal-Murphy, Michaela ;

Bastl, Klavdija ;

Pisa, Hanja ;

Knab, Vanessa M. ;

Brandstoetter, Tania ;

Doma, Eszter ;

Sperr, Wolfgang R. ;

Lagger, Sabine ;

Farlik, Matthias ;

Moriggl, Richard ;

Valent, Peter ;

Halbritter, Florian ;

Kollmann, Karoline ;

Heller, Gerwin ;

Maurer, Barbara ;

Sexl, Veronika .

BLOOD, 2021, 138 (23) :2347-2359

[5] Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia [J].

Maude, Shannon L. ;

Dolai, Sibasish ;

Delgado-Martin, Cristina ;

Vincent, Tiffaney ;

Robbins, Alissa ;

Selvanathan, Arthavan ;

Ryan, Theresa ;

Hall, Junior ;

Wood, Andrew C. ;

Tasian, Sarah K. ;

Hunger, Stephen P. ;

Loh, Mignon L. ;

Mullighan, Charles G. ;

Wood, Brent L. ;

Hermiston, Michelle L. ;

Grupp, Stephan A. ;

Lock, Richard B. ;

Teachey, David T. .

BLOOD, 2015, 125 (11) :1759-1767

[6] The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors [J].

Nelson, Erik A. ;

Walker, Sarah R. ;

Weisberg, Ellen ;

Bar-Natan, Michal ;

Barrett, Rosemary ;

Gashin, Laurie B. ;

Terrell, Shariya ;

Klitgaard, Josephine L. ;

Santo, Loredana ;

Addorio, Martha R. ;

Ebert, Benjamin L. ;

Griffin, James D. ;

Frank, David A. .

BLOOD, 2011, 117 (12) :3421-3429

[7] Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives [J].

Rondanin, Riccardo ;

Simoni, Daniele ;

Romagnoli, Romeo ;

Baruchello, Riccardo ;

Marchetti, Paolo ;

Costantini, Cristiana ;

Fochi, Sara ;

Padroni, Giacomo ;

Grimaudo, Stefania ;

Pipitone, Rosaria Maria ;

Meli, Maria ;

Tolomeo, Manlio .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (18) :4568-4574

[8] Suppressing STAT5 signaling affects osteosarcoma growth and stemness [J].

Subramaniam, Dharmalingam ;

Angulo, Pablo ;

Ponnurangam, Sivapriya ;

Dandawate, Prasad ;

Ramamoorthy, Prabhu ;

Srinivasan, Pugazhendhi ;

Iwakuma, Tomoo ;

Weir, Scott J. ;

Chastain, Katherine ;

Anant, Shrikant .

CELL DEATH & DISEASE, 2020, 11 (02)

[9] COSMIC: the Catalogue Of Somatic Mutations In Cancer [J].

Tate, John G. ;

Bamford, Sally ;

Jubb, Harry C. ;

Sondka, Zbyslaw ;

Beare, David M. ;

Bindal, Nidhi ;

Boutselakis, Harry ;

Cole, Charlotte G. ;

Creatore, Celestino ;

Dawson, Elisabeth ;

Fish, Peter ;

Harsha, Bhavana ;

Hathaway, Charlie ;

Jupe, Steve C. ;

Kok, Chai Yin ;

Noble, Kate ;

Ponting, Laura ;

Ramshaw, Christopher C. ;

Rye, Claire E. ;

Speedy, Helen E. ;

Stefancsik, Ray ;

Thompson, Sam L. ;

Wang, Shicai ;

Ward, Sari ;

Campbell, Peter J. ;

Forbes, Simon A. .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D941-D947

[10] STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia [J].

Tremblay, Cedric S. ;

Saw, Jesslyn ;

Boyle, Jacqueline A. ;

Haigh, Katharina ;

Litalien, Veronique ;

McCalmont, Hannah ;

Evans, Kathryn ;

Lock, Richard B. ;

Jane, Stephen M. ;

Haigh, Jody J. ;

Curtis, David J. .

BLOOD, 2023, 142 (03) :274-289

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