Teriflunomide: an oral therapy for first-line treatment of children and adolescents living with relapsing-remitting multiple sclerosis

被引:1
作者
Dalla Costa, Gloria [1 ]
Comi, Giancarlo [1 ,2 ,3 ]
机构
[1] Univ Vita Salute San Raffaele, Fac Med, Milan, Italy
[2] Casa Cura Igea, Multiple Sclerosis Ctr, Milan, Italy
[3] Ctr Casa Cura Igea, Multiple Sclerosis Ctr, Via Dezza 48, Milan, Italy
关键词
Pediatric MS; Teriflunomide; Relapsing-remitting course; Efficacy; Safety; Demyelination; INTERFERON BETA-1A; PSYCHOSOCIAL FEATURES; CLINICAL-FEATURES; JUVENILE MS; CHILDHOOD; TRIAL;
D O I
10.1080/14737175.2023.2229953
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
IntroductionDifferent disease-modifying therapies (DMTs) have been developed to slow down the progression of pediatric multiple sclerosis (MS). Teriflunomide is one such DMT that has recently been approved for use in pediatric MS in the European Union.Areas coveredThe article provides an introduction to the mechanism of action of teriflunomide, reviews the clinical trials conducted on the safety and efficacy of the drug, and the optimal dosing and monitoring strategies.Expert opinionTeriflunomide is an oral medication that has shown promise in improving outcomes for pediatric MS patients, including reduced relapse rates and improved quality of life. However, more research is needed to determine its long-term safety in pediatric patients. As MS often presents with an aggressive course in children, the choice of disease-modifying treatment should be carefully evaluated, with a preference for second-line therapy. Despite the potential benefits of teriflunomide, changes in clinical practice may be hindered by factors such as cost and physician familiarity with alternative treatments. Longer-term studies and biomarker identification are areas for improvement, but the future of research in this area holds promise for the continued development and refinement of disease-modifying therapies and more personalized, targeted treatments for pediatric MS patients.
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收藏
页码:681 / 687
页数:7
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