Micro-nano porous structured tantalum-coated dental implants promote osteogenic activity in vitro and enhance osseointegration in vivo

被引：12
作者：
Cui, Jiantong [1 ,2 ]
Zhang, Shaoqing [1 ,3 ]
Huang, Meng [1 ]
Mu, Xiaodan [2 ]
Hei, Junhao [1 ,2 ]
Yau, Vicky [4 ,5 ]
He, Huixia [2 ,6 ,7 ]
机构：
[1] Chinese PLA, Dept Stomatol, Med Sch, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Stomatol, Beijing 100853, Peoples R China
[3] CangZhou Stomatol Hosp, Dept Endodont, Cangzhou 061011, Hebei, Peoples R China
[4] New York Presbyterian Columbia Univ Irving Med Ctr, Div Oral & Maxillofacial Surg, New York, NY 11791 USA
[5] New York Presbyterian Columbia Univ Irving Med Ctr, New York, NY 11791 USA
[6] Chinese Peoples Liberat Army Gen Hosp, Dept Stomatol, 28 Fuxing Rd, Beijing 100853, Peoples R China
[7] Chinese PLA Med Sch, 28 Fuxing Rd, Beijing 100853, Peoples R China
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2023年 / 111卷 / 09期
基金：
国家高技术研究发展计划(863计划);
关键词：
osteogenic differentiation; osteointegration; tantalum; vacuum plasma spraying; CELL-ADHESION; EARLY-STAGE; SURFACE; TITANIUM; BONE; DEPOSITION; MORPHOLOGY; WEAR;
D O I：
10.1002/jbm.a.37538
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Due to its excellent biocompatibility and corrosion resistance, tantalum demonstrates versatility as an implant material. However, limited studies investigated the role of tantalum coated titanium-based dental implants. This study aimed to investigate the potential application of micro-nano porous structured tantalum coating on the surface of titanium dental implant. In the present study, micro-nano porous structured tantalum coating was prepared by vacuum plasma spraying (VPS) under selected optimum parameters, various characteristics of tantalum coating (Ta/Ti), including the morphology, potential, constituent, and hydrophilia, were investigated in comparison with its respective control groups, sandblasted titanium (Ti) and titanium coating (Ti/Ti). The adhesion, proliferation, and osteogenic differentiation ability of rat bone marrow mesenchymal cells (BMSCs) on different materials were assessed in vitro. Then the osseointegration capacity of Ti, Ti/Ti, Ta/Ti, and Straumann implants in canine mandible was evaluated with micro-CT, histological sections, and energy dispersive X-ray spectroscopy. These results demonstrated that micro-nanostructured, uneven, and granular tantalum coating was successfully prepared on titanium substrate by VPS with pore size ranging from 50 nm to 5 mu m and thickness ranging from 80 to 100 mu m. Tantalum coating revealed the highest surface potential, best hydrophilia, and most protein adsorption among Ta/Ti, Ti/Ti, and Ti. Furthermore, Ta/Ti surfaces significantly promoted the adhesion, proliferation, and osteogenic differentiation of BMSCs. In vivo, Ta/Ti implants displayed positive osseointegration capability associated with increased bone mineral density and formation of new bone around implants without tantalum particles released. Together, these findings indicate that tantalum-coated titanium dental implants may serve as a new type of dental implant.
引用
收藏
页码：1358 / 1371
页数：14
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