GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy

被引：9

作者：

Zhang, Miao ^{[1
]}

Tan, Yanzhen ^{[2
]}

Song, Yujie ^{[2
]}

Zhu, Min ^{[1
]}

Zhang, Bing ^{[2
]}

Chen, Cheng ^{[1
]}

Liu, Yingying ^{[2
]}

Shi, Lei ^{[2
]}

Cui, Jun ^{[2
]}

Shan, Wenju ^{[1
]}

Jia, Zipei ^{[1
]}

Feng, Lele ^{[2
]}

Cao, Guojie ^{[1
]}

Yi, Wei ^{[2
]}

Sun, Yang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Gen Med, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian 710032, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 161卷

基金：

中国国家自然科学基金;

关键词：

Gastrodin; Cardiac hypertrophy; GLUT4; INJURY; LIVER;

D O I：

10.1016/j.biopha.2023.114324

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gastrodia elata exhibits extensive pharmacological activity; its extract gastrodin (GAS) has been used clinically to treat cardiovascular diseases. In the present study, we examined the effect of GAS in a mice model of pathological cardiac hypertrophy, which was induced using transverse aortic constriction (TAC). Male C57BL/6 J mice un-derwent either TAC or sham surgery. GAS was administered post-surgically for 6 weeks and significantly improved the deterioration of cardiac contractile function caused by pressure overload, cardiac hypertrophy, and fibrosis in mice. Treatment with GAS for 6 weeks upregulated myosin heavy chain alpha and down-regulated myosin heavy chain beta and atrial natriuretic peptide, while insulin increased the effects of GAS against cardiac hyper-trophy. In vitro studies showed that GAS could also protect phenylephrine-induced cardiomyocyte hypertrophy, and these effects were attenuated by BAY-876, and increased by insulin. Taken together, our results suggest that the anti-hypertrophic effect of gastrodin depends on its entry into cardiomyocytes through GLUT4.

引用

页数：10

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