The Role of m6A Modifications in B-Cell Development and B-Cell-Related Diseases

被引：6
作者：
Wang, Shuqi [1 ]
Li, Huanxiang [1 ]
Lian, Zhengxing [1 ]
Deng, Shoulong [2 ,3 ]
机构：
[1] China Agr Univ, Coll Anim Sci & Technol, Beijing Key Lab Anim Genet Improvement, Natl Engn Lab Anim Breeding,Key Lab Anim Genet & B, Beijing 100193, Peoples R China
[2] Chinese Acad Med Sci, Inst Lab Anim Sci, NHC Key Lab Human Dis Comparat Med, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Comparat Med Ctr, Beijing 100021, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期
关键词：
B cell; immunodeficiency; m(6)A; B-cell-related diseases; COMMON VARIABLE IMMUNODEFICIENCY; X-LINKED AGAMMAGLOBULINEMIA; HEMATOPOIETIC STEM-CELL; MESSENGER-RNA METHYLATION; GENE-EXPRESSION; T-CELLS; LINEAGE SPECIFICATION; ANTIGEN-RECEPTOR; CD40; LIGAND; METHYLTRANSFERASE;
D O I：
10.3390/ijms24054721
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m(6)A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three m(6)A modification-related regulators-writer, eraser, and reader-in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases.
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页数：13
相关论文
共 128 条
[1]   Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future [J].
Ahmed, Aisha ;
Lippner, Elizabeth ;
Khanolkar, Aaruni .
CELLS, 2022, 11 (21)
[2]   Role of B cells in common variable immune deficiency [J].
Ahn, Sam ;
Cunningham-Rundles, Charlotte .
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2009, 5 (05) :557-564
[3]   HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].
Alarcon, Claudio R. ;
Goodarzi, Hani ;
Lee, Hyeseung ;
Liu, Xuhang ;
Tavazoie, Saeed ;
Tavazoie, Sohail F. .
CELL, 2015, 162 (06) :1299-1308
[4]   N6-methyladenosine marks primary microRNAs for processing [J].
Alarcon, Claudio R. ;
Lee, Hyeseung ;
Goodarzi, Hani ;
Halberg, Nils ;
Tavazoie, Sohail F. .
NATURE, 2015, 519 (7544) :482-+
[5]   Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages [J].
Arinobu, Yojiro ;
Mizuno, Shin-ichi ;
Chong, Yong ;
Shigematsu, Hirokazu ;
Lino, Tadafumi ;
Iwasaki, Hiromi ;
Graf, Thomas ;
Mayfield, Robin ;
Chan, Susan ;
Kastner, Philippe ;
Akashi, Koichi .
CELL STEM CELL, 2007, 1 (04) :416-427
[6]   The m6A Writer: Rise of a Machine for Growing Tasks [J].
Balacco, Dario L. ;
Soller, Matthias .
BIOCHEMISTRY, 2019, 58 (05) :363-378
[7]   MODOMICS: a database of RNA modification pathways. 2021 update [J].
Boccaletto, Pietro ;
Stefaniak, Filip ;
Ray, Angana ;
Cappannini, Andrea ;
Mukherjee, Sunandan ;
Purta, Elzbieta ;
Kurkowska, Malgorzata ;
Shirvanizadeh, Niloofar ;
Destefanis, Eliana ;
Groza, Paula ;
Avsar, Gulben ;
Romitelli, Antonia ;
Pir, Pinar ;
Dassi, Erik ;
Conticello, Silvestro G. ;
Aguilo, Francesca ;
Bujnicki, Janusz M. .
NUCLEIC ACIDS RESEARCH, 2022, 50 (D1) :D231-D235
[8]   Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease [J].
Bohnsack, Katherine E. ;
Hoebartner, Claudia ;
Bohnsack, Markus T. .
GENES, 2019, 10 (02)
[9]  
Bokar JA, 1997, RNA, V3, P1233
[10]  
BOKAR JA, 1994, J BIOL CHEM, V269, P17697
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