Prevalence of Multidrug-Resistant Organisms in Healthy Adults in Shenzhen, China

被引：3

作者：

Liu, Ding ^{[1
]}

Li, Guiqiu ^{[2
]}

Hong, Zhifan ^{[1
]}

Zhang, Cong ^{[1
]}

Zhu, Ning ^{[1
]}

Tan, Yan ^{[1
]}

Gao, Ting ^{[1
,3
]}

机构：

[1] Shenzhen Xbiome Biotech Ltd, Shenzhen, Peoples R China

[2] Huazhong Univ Sci & Technol Union, Shenzhen Hosp, Clin Lab Med Ctr, Shenzhen, Peoples R China

[3] Sci Res Bldg,Room 907,Tsinghua High-Tech Pk, Shenzhen 518057, Peoples R China

来源：

HEALTH SECURITY | 2023年 / 21卷 / 02期

关键词：

Multidrug resistance; Metagenomic sequencing; Public health preparedness; response; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; ANTIMICROBIAL RESISTANCE; STAPHYLOCOCCUS-AUREUS; COLONIZATION; SURVEILLANCE; INFECTIONS;

D O I：

10.1089/hs.2022.0111

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Public health problems caused by the high transmission of multidrug-resistant organisms (MDROs) have attracted widespread international attention. However, studies on healthy adults in this field are scarce. In this article, we report the microbiological screening results of 180 healthy adults recruited from 1,222 participants between 2019 and 2022 in Shenzhen, China. Findings show a high MDRO carriage rate of 26.7% in those individuals who did not use any antibiotics in the past 6 months and had not been hospitalized within the past year. MDROs were mainly extended-spectrum beta-lactamase-producing Escherichia coli with high resistance to cephalosporin. With the assistance of metagenomic sequencing technology, we also performed long-term observations of several participants and found that drug-resistant gene fragments were prevalent even when MDROs were not detected by drug sensitivity testing. Based on our findings, we suggest that healthcare regulators limit the medical overuse of antibiotics and enact measures to limit its nonmedical use.

引用

页码：122 / 129

页数：8

共 35 条

[1] A multinational study of colonization with extended spectrum β-lactamase-producing Enterobacteriaceae in healthcare personnel and family members of carrier patients hospitalized in rehabilitation centres [J].

Adler, A. ;

Baraniak, A. ;

Izdebski, R. ;

Fiett, J. ;

Salvia, A. ;

Samso, J. V. ;

Lawrence, C. ;

Solomon, J. ;

Paul, M. ;

Lerman, Y. ;

Schwartzberg, Y. ;

Mordechai, E. ;

Rossini, A. ;

Fierro, J. ;

Lammens, C. ;

Malhotra-Kumar, S. ;

Goossens, H. ;

Hryniewicz, W. ;

Brun-Buisson, C. ;

Gniadkowski, M. ;

Carmeli, Y. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (08) :O516-O523

[2] CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database [J].

Alcock, Brian P. ;

Raphenya, Amogelang R. ;

Lau, Tammy T. Y. ;

Tsang, Kara K. ;

Bouchard, Megane ;

Edalatmand, Arman ;

Huynh, William ;

Nguyen, Anna-Lisa, V ;

Cheng, Annie A. ;

Liu, Sihan ;

Min, Sally Y. ;

Miroshnichenko, Anatoly ;

Tran, Hiu-Ki ;

Werfalli, Rafik E. ;

Nasir, Jalees A. ;

Oloni, Martins ;

Speicher, David J. ;

Florescu, Alexandra ;

Singh, Bhavya ;

Faltyn, Mateusz ;

Hernandez-Koutoucheva, Anastasia ;

Sharma, Arjun N. ;

Bordeleau, Emily ;

Pawlowski, Andrew C. ;

Zubyk, Haley L. ;

Dooley, Damion ;

Griffiths, Emma ;

Maguire, Finlay ;

Winsor, Geoff L. ;

Beiko, Robert G. ;

Brinkman, Fiona S. L. ;

Hsiao, William W. L. ;

Domselaar, Gary, V ;

McArthur, Andrew G. .

NUCLEIC ACIDS RESEARCH, 2020, 48 (D1) :D517-D525

[3]

Clinical Laboratory Standards Institute, 2022, Performance standards for antimicrobial susceptibility testing, V32nd

[4] Prevalence of multidrug-resistant organisms in migrant children admitted to an Italian cardiac surgery department, 2015-2016 [J].

Costa, E. ;

Tejada, M. ;

Gaia, P. ;

Cornetta, M. ;

Moroni, A. ;

Carfora, E. ;

Valaperta, R. ;

De Siena, C. ;

Moussaidi, N. ;

Isgro, G. ;

Frigiola, A. .

JOURNAL OF HOSPITAL INFECTION, 2018, 98 (03) :309-312

[5] Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant [J].

DeFilipp, Zachariah ;

Bloom, Patricia P. ;

Soto, Mariam Torres ;

Mansour, Michael K. ;

Sater, Mohamad R. A. ;

Huntley, Miriam H. ;

Turbett, Sarah ;

Chung, Raymond T. ;

Chen, Yi-Bin ;

Hohmann, Elizabeth L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (21) :2043-2050

[6] Retraction of DNA-bound type IV competence pili initiates DNA uptake during natural transformation in Vibrio cholerae [J].

Ellison, Courtney K. ;

Dalia, Triana N. ;

Ceballos, Alfredo Vidal ;

Wang, Joseph Che-Yen ;

Biais, Nicolas ;

Brun, Yves V. ;

Dalia, Ankur B. .

NATURE MICROBIOLOGY, 2018, 3 (07) :773-+

[7] The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017 [J].

European Food Safety AuthorityEuropean Centre for Disease Prevention and Control .

EFSA JOURNAL, 2019, 17 (02)

[8] Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France [J].

Farfour, Eric ;

Dortet, Laurent ;

Guillard, Thomas ;

Chatelain, Nicolas ;

Poisson, Agathe ;

Mizrahi, Assaf ;

Fournier, Damien ;

Bonnin, Remy A. ;

Degand, Nicolas ;

Morand, Philippe ;

Janvier, Frederic ;

Fihman, Vincent ;

Corvec, Stephane ;

Broutin, Lauranne ;

Le Brun, Cecile ;

Yin, Nicolas ;

Hery-Arnaud, Genevieve ;

Grillon, Antoine ;

Bille, Emmanuelle ;

Jean-Pierre, Helene ;

Amara, Marlene ;

Jaureguy, Francoise ;

Isnard, Christophe ;

Cattoir, Vincent ;

Diedrich, Tristan ;

Flevin, Emilie ;

Merens, Audrey ;

Jacquier, Herve ;

Vasse, Marc .

PATHOGENS, 2022, 11 (03)

[9] Species-level functional profiling of metagenomes and metatranscriptomes [J].

Franzosa, Eric A. ;

McIver, Lauren J. ;

Rahnavard, Gholamali ;

Thompson, Luke R. ;

Schirmer, Melanie ;

Weingart, George ;

Lipson, Karen Schwarzberg ;

Knight, Rob ;

Caporaso, J. Gregory ;

Segata, Nicola ;

Huttenhower, Curtis .

NATURE METHODS, 2018, 15 (11) :962-+

[10] Colonization by multidrug-resistant organisms in long-term care facilities in Italy: a point-prevalence study [J].

Giufre, M. ;

Ricchizzi, E. ;

Accogli, M. ;

Barbanti, F. ;

Monaco, M. ;

de Araujo, F. Pimentel ;

Farina, C. ;

Fazii, P. ;

Mattei, R. ;

Sarti, M. ;

Barozzi, A. ;

Buttazzi, R. ;

Cosentino, M. ;

Nardone, M. ;

Savini, V. ;

Spigaglia, P. ;

Pantosti, A. ;

Moro, M. L. ;

Cerquetti, M. .

CLINICAL MICROBIOLOGY AND INFECTION, 2017, 23 (12) :961-967

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