Incidental Langerhans cell histiocytosis associated with metastatic neuroendocrine tumor in the adult liver

被引：0

作者：

Joseph, Nancy M. ^{[1
]}

Wen, Kwun Wah ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Pathol, 505 Parnassus Ave, M545, Box 0102, San Francisco, CA 94117 USA

来源：

CLINICAL CASE REPORTS | 2023年 / 11卷 / 02期

关键词：

BRAF mutation; langerhans cell histiocytosis (LCH); liver; neuroendocrine tumor (NET);

D O I：

10.1002/ccr3.6922

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is an unusual adult case of a metastatic well-differentiated neuroendocrine tumor with incidentally discovered subtle involvement of Langerhans cell histiocytosis (LCH), a clonal proliferation of Langerhans cells. It is important to recognize that LCH can often co-exist with other malignancies (solid > hematologic).

引用

页数：3

共 6 条

[1] Langerhans Cell Histiocytosis Associated With Renal Cell Carcinoma Is a Neoplastic Process Clinicopathologic and Molecular Study of 7 Cases [J].

Agaimy, Abbas ;

Bonert, Michael ;

Naqvi, Asghar ;

Wang, Chunjie ;

Trpkov, Kiril ;

Dettmar, Peer ;

Wintzer, Hanns-Olof ;

Stoehr, Robert ;

Hes, Ondrej ;

Williamson, Sean R. ;

Gibson, Ian W. ;

Hartmann, Arndt .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2020, 44 (12) :1658-1665

[2] Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients [J].

Bagnasco, Francesca ;

Zimmermann, Stefanie Yvonne ;

Egeler, Rudolph Maarten ;

Nanduri, Vasanta Rao ;

Cammarata, Bruna ;

Donadieu, Jean ;

Lehrnbecher, Thomas ;

Haupt, Riccardo .

EUROPEAN JOURNAL OF CANCER, 2022, 172 :138-145

[3] DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors [J].

Jiao, Yuchen ;

Shi, Chanjuan ;

Edil, Barish H. ;

de Wilde, Roeland F. ;

Klimstra, David S. ;

Maitra, Anirban ;

Schulick, Richard D. ;

Tang, Laura H. ;

Wolfgang, Christopher L. ;

Choti, Michael A. ;

Velculescu, Victor E. ;

Diaz, Luis A., Jr. ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Hruban, Ralph H. ;

Papadopoulos, Nickolas .

SCIENCE, 2011, 331 (6021) :1199-1203

[4] Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies [J].

Ma, Jennifer ;

Laird, James H. ;

Chau, Karen W. ;

Chelius, Monica R. ;

Lok, Benjamin H. ;

Yahalom, Joachim .

CANCER MEDICINE, 2019, 8 (01) :58-66

[5] Genomic landscape of pancreatic neuroendocrine tumours: the International Cancer Genome Consortium [J].

Mafficini, Andrea ;

Scarpa, Aldo .

JOURNAL OF ENDOCRINOLOGY, 2018, 236 (03) :R160-R167

[6] Whole-genome landscape of pancreatic neuroendocrine tumours [J].

Scarpa, Aldo ;

Chang, David K. ;

Nones, Katia ;

Corbo, Vincenzo ;

Patch, Ann-Marie ;

Bailey, Peter ;

Lawlor, Rita T. ;

Johns, Amber L. ;

Miller, David K. ;

Mafficini, Andrea ;

Rusev, Borislav ;

Scardoni, Maria ;

Antonello, Davide ;

Barbi, Stefano ;

Sikora, Katarzyna O. ;

Cingarlini, Sara ;

Vicentini, Caterina ;

McKay, Skye ;

Quinn, Michael C. J. ;

Bruxner, Timothy J. C. ;

Christ, Angelika N. ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

McLean, Suzanne ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Wilson, Peter J. ;

Anderson, Matthew J. ;

Fink, J. Lynn ;

Newell, Felicity ;

Waddell, Nick ;

Holmes, Oliver ;

Kazakoff, Stephen H. ;

Leonard, Conrad ;

Wood, Scott ;

Xu, Qinying ;

Nagaraj, Shivashankar Hiriyur ;

Amato, Eliana ;

Dalai, Irene ;

Bersanif, Samantha ;

Cataldo, Ivana ;

Tos, Angelo P. Dei ;

Capelli, Paola ;

Davi, Maria Vittoria ;

Landoni, Luca ;

Malpaga, Anna ;

Miotto, Marco ;

Whitehall, Vicki L. J. ;

Leggett, Barbara A. ;

Harris, Janelle L. .

NATURE, 2017, 543 (7643) :65-+

← 1 →