Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination

被引：3

作者：

Shen, Shuo-Jie ^{[1
]}

Li, Yao-Dong ^{[1
]}

Ge, Ye ^{[1
]}

Yang, Xu ^{[1
]}

Li, Lin-Hu ^{[1
,2
]}

Xu, Hua-Jin ^{[1
]}

Hu, Yi ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Pharmaceut Sci, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

[2] Limin Chem Co Ltd, Xinyi 221422, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 51期

基金：

中国国家自然科学基金;

关键词：

ACTIVATION; FUNCTIONALIZATION; ARENES; ANILINE; BONDS;

D O I：

10.1021/acs.orglett.3c03201

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Achieving high para-selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho-C-H bond. Herein, we report the ligand promoted high para-selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para-substituted benzoic acid derivatives.

引用

页码：9092 / 9096

页数：5

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