Expression signature and prognostic value of CREC gene family in human colorectal cancer

被引：6

作者：

Ning, Junya ^{[1
]}

Liu, Min ^{[1
]}

Shen, Jing ^{[1
]}

Wang, Deping ^{[1
]}

Gao, Lijuan ^{[1
]}

Li, Huiyu ^{[2
,3
]}

Cao, Jimin ^{[1
]}

机构：

[1] Shanxi Med Univ, Key Lab Cellular Physiol, Minist Educ, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Gen Surg,Hosp 1, Taiyuan 030032, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China

来源：

BMC CANCER | 2023年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CREC family; Expression signature; Colorectal cancer; Prognosis; Bioinformatics; HEPATOCELLULAR-CARCINOMA; INTERACTION NETWORKS; PROMOTES; CALUMENIN; CELLS; IDENTIFICATION; PROLIFERATION; RECURRENCE; BIOMARKERS; PROTEINS;

D O I：

10.1186/s12885-023-11303-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is one of the malignant tumors with the highest morbidity and mortality and poor prognosis. The mammalian gene family of Cab45/reticulocalbin/ERC-45/calumenin (CREC) consists of RCN1, RCN2, RCN3, SDF4 and CALU. Although CREC family members have been associated with CRC, the expression pattern, prognostic value, and the role of CREC family in CRC remain unclear. In this study, the expression, survival and biological functions of CREC family in CRC were determined via bioinformatic datasets analysis and experimental verification on clinical CRC specimen. Bioinformatic analysis showed that the expression levels of most CREC family genes were higher in CRC tissues than in normal colorectal tissues. The qPCR and western blot results also revealed that the transcriptional and protein levels of CREC family were elevated in CRC tissues compared with adjacent tissues. Besides, CREC family was significantly correlated with advanced tumor stage and poor prognosis of CRC patients. The expression levels of CREC family had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, macrophages, neutrophils, and dendritic cells in the microenvironment of CRC. Functional networks enrichment analysis indicated that the genes of CREC family were essential factors for CRC metastasis. Collectively, these findings suggest that CREC family might be potential targets for the treatment of CRC and candidate prognostic markers for CRC patients.

引用

页数：17

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