New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

被引：6
|
作者：
Li, Jialin [1 ]
Chen, Tao [1 ]
Yu, Jianchen [2 ]
Jia, Hao [1 ]
Chen, Chen [1 ]
Long, Yuhua [1 ]
机构：
[1] South China Normal Univ, Sch Chem, GDMPA Key Lab Proc Control & Qual Evaluat Chiral P, Guangzhou 510006, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biochem, Key Lab Trop Dis Control,Minist Educ, Guangzhou 510080, Peoples R China
来源：
MARINE DRUGS | 2023年 / 21卷 / 08期
基金：
中国国家自然科学基金;
关键词：
mangrove endophytic fungus; Trichoderma reesei; sorbicillinoids; SARS-CoV-2 inhibitory activity; molecular networking; METABOLITES; LONGIBRACHIATUM; BIOSYNTHESIS;
D O I：
10.3390/md21080442
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new dimeric sorbicillinoids (1-3) and one new 3,4,6-trisubstituted alpha-pyrone (5), along with seven analogues (4 and 6-11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC50 value of 29.0 mu M.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] New azaphilones from mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040
    Li, Jialin
    Li, Zixuan
    Chen, Tao
    Ye, Geting
    Qiu, Liyu
    Long, Yuhua
    NATURAL PRODUCT RESEARCH, 2023, 37 (02) : 296 - 304
  • [2] New steroids from mangrove-associated fungus Trichoderma asperellum SCNU-F0048
    Chen, Chen
    Liu, Lingling
    Ye, Siyao
    Li, Jialin
    Wu, Li
    Li, Junsen
    Jia, Hao
    Long, Yuhua
    STEROIDS, 2024, 208
  • [3] New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
    Li, Jialin
    Chen, Chen
    Fang, Tiantian
    Wu, Li
    Liu, Wenbin
    Tang, Jing
    Long, Yuhua
    MOLECULES, 2022, 27 (18):
  • [4] Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006
    Jia, Hao
    Wu, Li
    Liu, Rongrong
    Li, Jialin
    Liu, Lingling
    Chen, Chen
    Li, Junsen
    Zhang, Kai
    Liao, Junjiang
    Long, Yuhua
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (09)
  • [5] Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041
    Li, Jia-Lin
    Liu, Ling-Ling
    Lin, Zi-Rong
    Zeng, Hai-Qi
    Zhou, Zhe
    Long, Yu-Hua
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2025, 27 (04) : 632 - 638
  • [6] Sorbicillinoids from the alga-epiphytic fungus Trichoderma reesei Z56-8
    Ma, Xin-Yue
    Shi, Zhen-Zhen
    Ji, Nai-Yun
    NATURAL PRODUCT RESEARCH, 2023, 37 (03) : 369 - 374
  • [7] The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002
    Yan, Zhangyuan
    Wen, Shitong
    Ding, Meng
    Guo, Huixian
    Huang, Cuiying
    Zhu, Xintong
    Huang, Junyi
    She, Zhigang
    Long, Yuhua
    MARINE DRUGS, 2019, 17 (07):
  • [8] Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp Xy24
    Zhao, Jin-Lian
    Zhang, Min
    Liu, Ji-Mei
    Tan, Zhen
    Chen, Ri-Dao
    Xie, Ke-Bo
    Dai, Jun-Gui
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 19 (10) : 1028 - 1035
  • [9] A new cyclotetrapeptide from marine fungus Trichoderma reesei
    Sun, Yi
    Tian, Li
    Huang, Yong-Fu
    Sha, Yi
    Pei, Yue-Hu
    PHARMAZIE, 2006, 61 (09): : 809 - 810
  • [10] Tyrosinease from Trichoderma reesei fungus
    Selinheimo, Emilia
    Industrial Bioprocessing, 2006, 28 (10):
12345