TiCl4-catalyzed deoxygenative reduction of amides to amines using ammonia borane

被引：4
|
作者：
Zang, Yongjun [1 ,3 ]
Sui, Qibang [2 ]
Xu, Qilin [1 ]
Ma, Menghua [1 ]
Li, Guosi [1 ]
Zhu, Fucheng [1 ]
机构：
[1] West Anhui Univ, Tradit Chinese Med Inst Anhui Dabie Mt, Dept Biol & Pharmaceut Engn, Luan 237012, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[3] West Anhui Univ, Luan City 237012, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 124卷
关键词：
Deoxygenative reduction; Amides; Amines; Ammonia borane; TERTIARY AMIDES; HYDROBORATION REDUCTION; CATALYTIC-HYDROGENATION; KETONES; ALDEHYDES; SECONDARY;
D O I：
10.1016/j.tetlet.2023.154598
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and effective TiCl4-catalyzed procedure for the direct deoxygenative reduction of amides to corresponding amines has been developed using safe and stable ammonia borane (AB) as the reductant. This reduction protocol allows for a wide range of structurally diverse amine products in moderate to excellent yields, various functional groups such as halogen, nitro, and hydroxy groups were well toler-ated. This protocol could be performed without using any noble metal catalyst, inert atmosphere, dry sol-vent, and water scavenger.CO 2023 Elsevier Ltd. All rights reserved.
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页数：4
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