TiCl4-catalyzed deoxygenative reduction of amides to amines using ammonia borane

被引：4

作者：

Zang, Yongjun ^{[1
,3
]}

Sui, Qibang ^{[2
]}

Xu, Qilin ^{[1
]}

Ma, Menghua ^{[1
]}

Li, Guosi ^{[1
]}

Zhu, Fucheng ^{[1
]}

机构：

[1] West Anhui Univ, Tradit Chinese Med Inst Anhui Dabie Mt, Dept Biol & Pharmaceut Engn, Luan 237012, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] West Anhui Univ, Luan City 237012, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 124卷

关键词：

Deoxygenative reduction; Amides; Amines; Ammonia borane; TERTIARY AMIDES; HYDROBORATION REDUCTION; CATALYTIC-HYDROGENATION; KETONES; ALDEHYDES; SECONDARY;

D O I：

10.1016/j.tetlet.2023.154598

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and effective TiCl4-catalyzed procedure for the direct deoxygenative reduction of amides to corresponding amines has been developed using safe and stable ammonia borane (AB) as the reductant. This reduction protocol allows for a wide range of structurally diverse amine products in moderate to excellent yields, various functional groups such as halogen, nitro, and hydroxy groups were well toler-ated. This protocol could be performed without using any noble metal catalyst, inert atmosphere, dry sol-vent, and water scavenger.CO 2023 Elsevier Ltd. All rights reserved.

引用

页数：4

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